ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Chloropyrimidine >2,4-Dichloropyrimidine

2,4-Dichloropyrimidine

CAS No.: 3934-20-1

Chemical Name:: 2,4-Dichloropyrimidine

Synonyms: 2,4-dichloropyrimidine hydrochloride;2,4DCPY;NSC 20212;NSC 37531;NSC 49119;AKOS 91058;2,4-Dichlorpyrimidin;2,4-Dichloropyrimidi;4-DichloropyriMidine;Pazopanib Impurity 45

CBNumber:: CB6202781

Molecular Formula:: C4H2Cl2N2

Molecular Weight:: 148.98

MOL File:: 3934-20-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/25 20:04:51

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2,4-Dichloropyrimidine Properties

Melting point	57-61 °C (lit.)
Boiling point	101 °C/23 mmHg (lit.)
Density	1.6445 (rough estimate)
refractive index	1.6300 (estimate)
Flash point	101°C/23mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Powder, Crystals and/or Chunks
pka	-2.84±0.20(Predicted)
color	White to yellow to beige or grayish
Water Solubility	Soluble in water (partly), methanol, chloroform, and ethyl acetate.
Sensitive	Moisture Sensitive
BRN	110911
InChIKey	BTTNYQZNBZNDOR-UHFFFAOYSA-N
CAS DataBase Reference	3934-20-1(CAS DataBase Reference)
NIST Chemistry Reference	Pyrimidine, 2,4-dichloro-(3934-20-1)
EPA Substance Registry System	Pyrimidine, 2,4-dichloro- (3934-20-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-28A

RIDADR

1759

WGK Germany

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29335990

NFPA 704

	1
2		0

2,4-Dichloropyrimidine price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	143847	2,4-Dichloropyrimidine 98%	3934-20-1	10G	₹4940	2022-06-14	Buy
Sigma-Aldrich(India)	143847	2,4-Dichloropyrimidine 98%	3934-20-1	50G	₹13860	2022-06-14	Buy
TCI Chemicals (India)	D2310	2,4-Dichloropyrimidine min. 98.0 %	3934-20-1	5G	₹3400	2022-05-26	Buy
TCI Chemicals (India)	D2310	2,4-Dichloropyrimidine min. 98.0 %	3934-20-1	25G	₹8200	2022-05-26	Buy

Product number	Packaging	Price	Buy
143847	10G	₹4940	Buy
143847	50G	₹13860	Buy
D2310	5G	₹3400	Buy
D2310	25G	₹8200	Buy

2,4-Dichloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

2,4-Dichloropyrimidine was used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles.

Preparation

Obtained by chlorination of uracil. Add uracil, phosphorus trichloride, and xylene amine into the reaction pot, heat to 130 ℃, reflux for about 45min, slightly cool, put in crushed ice, that is, the precipitation of purple solid, filtered while hot and not dissolved, washed with ice water, vacuum drying, a kind of purple crude, decolorized with petroleum ether (boiling range of 60-90 ℃), recrystallized, obtained 2,4-dichloropyrimidine.

General Description

2,4-Dichloropyrimidine is a human skin sensitizer. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines.

Reactivity Profile

The reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline and 2,4-dichloro-5-methyl-pyrimidine afforded 2-amino-4-chloroquinazolines and 2-amino-4-chloro-5-methylpyrimidines, respectively—the reaction of these amines with 2,4-dichloropyrimidine 3a afforded not only 2-amino-4-chloropyrimidines but also the isomeric 4-amino-2-chloropyrimidines. An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed. This method enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and correspondingly lower temperatures than polar aprotic solvents[5-6].

References

[1] DR. AGNES FIZIA. Cyclopalladation in the Periphery of a NHC Ligand as the Crucial Step in the Synthesis of Highly Active Suzuki–Miyaura Cross-Coupling Catalysts[J]. Chemistry - A European Journal, 2017. DOI:10.1002/chem.201702877.
[2] FABIAN BRUENING Lucie E L. Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides[J]. European Journal of Organic Chemistry, 2017. DOI:10.1002/ejoc.201700459.
[3] ANDERSONSAMANTHA C HandyScott T. One-pot Double Suzuki Couplings of Dichloropyrimidines.[J]. Synthesis-Stuttgart, 2010. DOI:10.1055/s-0030-1258150.
[4] TOMá? KUBELKA. Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2′-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides[J]. European Journal of Organic Chemistry, 2010. DOI:10.1002/ejoc.201000164.
[5] Kenji Yoshida, M. Taguchi. “Reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline, 2,4-dichloropyrimidine, and its 5-methyl derivative.” Journal of The Chemical Society-perkin Transactions 1 102 1 (1992): 919–922.
[6] Samantha C Anderson, Scott T Handy. “One-pot Double Suzuki Couplings of Dichloropyrimidines.” Synthesis-Stuttgart 2010 16 (2010): 2721–2724.

2,4-Dichloropyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxychloride Uracil Xylidine

Preparation Products

5-FORMYL-2,4-DIMETHOXYPYRIMIDINE (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE 2,4-DIETHOXYPYRIMIDINE 2,4-Dimethoxypyrimidine 4-Hydroxypyrimidine

Chlorimuron-ethyl 4-BENZYLOXY-2-CHLOROPYRIMIDINE 5-Iodo-2,4-dimethoxypyrimidine 4-Amino-2-chloropyrimidine 2-CHLORO-4-(N,N-DIMETHYLAMINO)PYRIMIDINE

2-Chloro-4-hydrazinopyrimidine 2-CHLORO(BROMO)PYRIMIDINE N4-Methylcytosine 2-CHLORO-4-METHOXYPYRIMIDINE 2,4-DIFLUOROPYRIMIDINE

4-(3-Pyridyl)-2-chloropyrimidine Benzyl-(2-chloro-pyrimidin-4-yl)-methyl-amine Phenol, 5-[(2-chloro-4-pyrimidinyl)amino]-2-methyl-

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2,4-Dichloropyrimidine Suppliers

Global( 819)Suppliers

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Supplier	Advantage
BTC pharm India	58
GLR Innovations	58
Kalam Sai Life Sciences Pvt Ltd	58
NSR Laboratories Pvt. Ltd.	58
SAGAR LIFE SCIENCES PVT LTD	58
LIFECHEM PHARMA	58
HEMANT BIOSCIENCE	58
SURVIVAL TECHNOLOGIES LIMITED	58
SRC Laboratories Pvt Ltd	58
Vijayasai Lifesciences	58

2,4-Dichloropyrimidine Spectrum

2,4-Dichloropyrimidine(3934-20-1)¹HNMR 2,4-Dichloropyrimidine(3934-20-1)IR1 2,4-Dichloropyrimidine(3934-20-1)Raman

3934-20-1(2,4-Dichloropyrimidine)Related Search:

4,6-Dichloropyrimidine ,98%,4 6-DICHLOROPYRIMIDINE 99% 2-Amino-4,6-dimethylpyrimidine 2-Amino-4,6-dimethoxypyrimidine 3-Methyl-6-nitroindazole 2-Ethyl-5-nitrobenzenamine ,98%

5-Amino-2-methylbenzenesulfonamide N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32

Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl-

1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- 6-Nitroindazole Pazopanib Impurity 48

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2,4-DICHLOROPYRIMIDINE 2,6-DICHLOROPYRIMIDINE 2-4-DICHLOROPYRIMIDINE CRYSTALLINE AKOS 91058 2,4-dichloro-pyrimidin 2,4-Dichlorpyrimidin Pyrimidine,2,4-dichloro- 2,4DCPY 2,4-Dichloropyrimidine, 98+% Pyrimidine, 2,4-dichloro- (7CI,8CI,9CI) 2,4-Dichloropyrimidine, GC 97% 2,4-Dichloropyrimidine ,97% 2,4-Dichloropyrimidi 4-DichloropyriMidine 2,4-Dichloro-1,3-diazine 2,4-DichloropyriMidine, 97% 25GR 2-ChloropyriMidin-4-yl Chloride NSC 20212 NSC 37531 NSC 49119 2,4-Dichloropyrimidine, 97%, for synthesis 2,4-Dichloropyrimidine Pazopanib 2,4-dichloro pyrimidine( 2,4-DCP) Pazopanib Impurity 45 2,4-Dichloropyrimidine> 2,4-dichloropyrimidine hydrochloride 2-naphthalen-5-ylethanamine 2,4-dichloro pyrimdine 2,4-Dichloropyrimidine / Osimertinib intermediate DichloroPyrimidine-2,4 2,4-Dichioropyrimidine 3934-20-1 C4H2N2Cl2 C4H2Cl2N2 C4H2N2CI2 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines HETERO CHLORIDE Halides Pyrazines, Pyrimidines & Pyridazines Aromatics Heterocycles Pyrazines, Pyrimidines & Pyridazines Heterocycle-Pyrimidine series PYRIMIDINE Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Heterocyclic Compounds Building Blocks Aromatics Compounds Pyrimidines Pyrimidine Series Pyridines, Pyrimidines, Purines and Pteredines bc0001