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ChemicalBook > Product Catalog >Organic Chemistry >Amides >2-amino-5-methylbenzenesulfonamide

2-amino-5-methylbenzenesulfonamide

2-amino-5-methylbenzenesulfonamide Structure
CAS No.
609-55-2
Chemical Name:
2-amino-5-methylbenzenesulfonamide
Synonyms
NSC57677;Pazopanib Impurity 60;2-amino-5-methylbenzenesulfomide;2-amino-5-methylbenzenesulfonamide;2-amino-4-methylbenzenesulfonamide;2-azanyl-5-methyl-benzenesulfonamide;Benzenesulfonamide, 2-amino-5-methyl-;Benzenesulfonamide, 2-amino-5-methyl- (9CI)
CBNumber:
CB71040804
Molecular Formula:
C7H10N2O2S
Molecular Weight:
186.23
MOL File:
609-55-2.mol
Modify Date:
2023/10/18 9:04:46
Request For Quotation

2-amino-5-methylbenzenesulfonamide Properties

storage temp. 2-8°C
InChI InChI=1S/C7H10N2O2S/c1-5-2-3-6(8)7(4-5)12(9,10)11/h2-4H,8H2,1H3,(H2,9,10,11)
InChIKey GKTVIFGJASUBGA-UHFFFAOYSA-N
SMILES C1(S(N)(=O)=O)=CC(C)=CC=C1N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H335-H319-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

2-amino-5-methylbenzenesulfonamide Chemical Properties,Uses,Production

Uses

2-amino-5-methylbenzenesulfonamide is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. It could reacted with triethyl orthoformate to give 7-Methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide by ring closure. It was an intermediate of potent AMPA receptor potentiators[1].

Synthesis

A solution of 7-methyl-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (10, 10 g, 47,12 mmol) in sulfuric acid 50% (150 mL) was refluxed until complete dissolution of the suspension. At the end of the reaction, the solution was adjusted to pH 7 with an aqueous solution of concentrated NaOH. The solvent was removed by distillation under reduced pressure. The residue was triturated with methanol and the salts were eliminated by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was triturated in water (a minimum). The resulting precipitate was collected by filtration, washed with water, and dried to afford 2-amino-5-methylbenzenesulfonamide[1].

References

[1] Dintilhac G, et al. New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. RSC Medicinal Chemistry, 2011; 2: 509-523.

2-amino-5-methylbenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-amino-5-methylbenzenesulfonamide Suppliers

Global( 37)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
PT CHEM GROUP LIMITED +86-85511178 +86-85511178 China 35451 58 Inquiry
ZHEJIANG JIUZHOU CHEM CO., LTD +86-0576225566889 +86-13454675544 China 19947 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
DSL Chemicals Co.，Ltd +86 21 6352 9955 China 6985 65 Inquiry
Wuhan Yanzhe Technology Co., Ltd 15527250409 China 4576 58 Inquiry
Supplier Advantage
Capot Chemical Co.,Ltd. 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
PT CHEM GROUP LIMITED 58
ZHEJIANG JIUZHOU CHEM CO., LTD 58
GIHI CHEMICALS CO.,LIMITED 58
Amadis Chemical Company Limited 58
DSL Chemicals Co.，Ltd 65
Wuhan Yanzhe Technology Co., Ltd 58

609-55-2(2-amino-5-methylbenzenesulfonamide)Related Search:

5-Amino-2-methylbenzenesulfonamide 3-Methyl-6-nitroindazole 2-Ethyl-5-nitrobenzenamine ,98% N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48
3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32 2,4-Dichloropyrimidine Benzenamine, 2-ethyl-4-nitro-
Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- 6-Nitroindazole 3-AMINO-4-METHYLBENZENESULFONAMIDE
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2-amino-5-methylbenzenesulfonamide Benzenesulfonamide, 2-amino-5-methyl- (9CI) NSC57677 Benzenesulfonamide, 2-amino-5-methyl- 2-azanyl-5-methyl-benzenesulfonamide 2-amino-4-methylbenzenesulfonamide 2-amino-5-methylbenzenesulfomide Pazopanib Impurity 60 609-55-2 SULFONAMIDE