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ChemicalBook > Product Catalog >Organic Chemistry >Heterocyclic Compounds >6-Nitroindazole

6-Nitroindazole

6-Nitroindazole Structure
CAS No.
7597-18-4
Chemical Name:
6-Nitroindazole
Synonyms
6-NITRO-1H-INDAZOLE;6-Nitrobrazol;6-NITROINDAZOLE;6-Nitroindazoles;6-Nitroisoindazole;6-nitro-1h-indazol;6-Nitroindazole>6-Nitroindazole 97%;6-Nitroindazole,98%;6-Nitroindazole ,97%
CBNumber:
CB8358413
Molecular Formula:
C7H5N3O2
Molecular Weight:
163.13
MOL File:
7597-18-4.mol
MSDS File:
SDS
Modify Date:
2023/12/27 16:49:21
Request For Quotation

6-Nitroindazole Properties

Melting point 180-182 °C (lit.)
Boiling point 290.19°C (rough estimate)
Density 1.4141 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility very faint turbidity in hot Methanol
form Powder
pka 11.08±0.40(Predicted)
color Light Yellow
BRN 7812
CAS DataBase Reference 7597-18-4(CAS DataBase Reference)
NIST Chemistry Reference 6-Nitroindazole(7597-18-4)
EPA Substance Registry System 1H-Indazole, 6-nitro- (7597-18-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H351
Precautionary statements  P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-40-68-36
Safety Statements  26-27-36/37/39
WGK Germany  3
RTECS  NK7962100
TSCA  Yes
HS Code  29339900
NFPA 704
0
1 0

6-Nitroindazole price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) N17513 6-Nitroindazole 97% 7597-18-4 100G ₹7739.88 2022-06-14 Buy
TCI Chemicals (India) N0399 6-Nitroindazole 7597-18-4 25G ₹3200 2022-05-26 Buy
TCI Chemicals (India) N0399 6-Nitroindazole 7597-18-4 250G ₹13900 2022-05-26 Buy
Product number Packaging Price Buy
N17513 100G ₹7739.88 Buy
N0399 25G ₹3200 Buy
N0399 250G ₹13900 Buy

6-Nitroindazole Chemical Properties,Uses,Production

Description

6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].

Chemical Properties

yellow powder

Synthesis

6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated  acetonitrile.6-Nitroindazole

References

[1] HERRAIZTOMAS  GuillénHugo  AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.

6-Nitroindazole Preparation Products And Raw materials

Raw materials

Sodium nitrite 2-Methyl-5-nitroaniline Acetic acid

Preparation Products

6-Iodo-1H-indazole 6-AMINO-2-METHYL-2H-INDAZOLE (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine 1-METHYL-1H-INDAZOL-6-YLAMINE
2-Methyl-5-nitrophenol 3-Iodo-6-nitroindazole 6-Hydroxyindazole 5,6-dinitro-1H-indazole tert-butyl 6-nitro-1H-indazole-1-carboxylate
6-Nitro-1H-indazol-7-aMine 6-Aminoindazole
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6-Nitroindazole Suppliers

Global( 321)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
Vignasai Laboratories Pvt Ltd +91-9390048212 +91-9030998889 Telangana, India 99 58 Inquiry
SVH BIOSCIENCES +91-6303499280 +91-6303499280 Hyderabad, India 478 58 Inquiry
JAY CHEMICALS +91-9819633090 +91-9819633090 Maharashtra, India 85 58 Inquiry
Dr. Silviu Pharmachem Pvt., Ltd. +91-8390608382 +91-8390608382 Mumbai, India 248 58 Inquiry
BASR Fine Chemicals Pvt. Ltd. +91-9848230391 +91-9848230391 Telangana, India 908 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
VASIN BIO LIFE SCIENCES PVT LTD 9491644688 Hyderabad, India 2096 58 Inquiry
Dr. Silviu Pharmachem Pvt., Ltd. (DRSPL) 91-9665522151 Maharashtra, India 143 58 Inquiry
Supplier Advantage
GLR Innovations 58
Vignasai Laboratories Pvt Ltd 58
SVH BIOSCIENCES 58
JAY CHEMICALS 58
Dr. Silviu Pharmachem Pvt., Ltd. 58
BASR Fine Chemicals Pvt. Ltd. 58
TCI Chemicals (India) Pvt. Ltd. 58
CHEMSWORTH 30
VASIN BIO LIFE SCIENCES PVT LTD 58
Dr. Silviu Pharmachem Pvt., Ltd. (DRSPL) 58

6-Nitroindazole Spectrum

6-Nitroindazole(7597-18-4)1HNMR6-Nitroindazole(7597-18-4)13CNMR6-Nitroindazole(7597-18-4)IR16-Nitroindazole(7597-18-4)Raman

7597-18-4(6-Nitroindazole)Related Search:

3-Methyl-6-nitroindazole 3-Nitroacetophenone Sodium 3-nitrobenzenesulphonate 2-Ethyl-5-nitrobenzenamine ,98% 5-Amino-2-methylbenzenesulfonamide
N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32
2,4-Dichloropyrimidine Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6
2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- Pazopanib Impurity 47
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1H-Indazole, 6-nitro- 6-nitro-1h-indazol 6-Nitroisoindazole 6-NITROINDAZOLE 6-Nitro-1(2)H-indazole 6-Nitroindazole ,97% 6-Nitroindazole,98% 6-Nitroindazoles 6-Nitro-1H-indazole,97% 6-Nitroindazole 97% 6-Nitroindazole> 6-Nitrobrazol Pazopanib Impurity 59 6-NITRO-1H-INDAZOLE 7597-18-4 9597-18-4 Building Blocks Heterocyclic Building Blocks Indazoles Inhibitors Nitric Oxide Reagents Building Blocks Heterocyclic Building Blocks Heterocyclic Compounds All Inhibitors Indazoles Intermediate