2-Methyl-5-nitroaniline
- CAS No.
- 99-55-8
- Chemical Name:
- 2-Methyl-5-nitroaniline
- Synonyms
- FAST SCARLET G BASE;5-NITRO-O-TOLUIDINE;2-AMINO-4-NITROTOLUENE;PNOT;SCARLET G BASE;CI 37105;pnot[qr];NCI-C01843;dahongseji;ci37105[qr]
- CBNumber:
- CB7234387
- Molecular Formula:
- C7H8N2O2
- Molecular Weight:
- 152.15
- MOL File:
- 99-55-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/16 13:12:53
| Melting point | 103-106 °C(lit.) |
|---|---|
| Boiling point | 294.61°C (rough estimate) |
| Density | 1.2333 (estimate) |
| refractive index | 1.6276 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 2.34±0.10(Predicted) |
| color | Ochre to yellow-orange |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| BRN | 879021 |
| Exposure limits | ACGIH: TWA 1 mg/m3 |
| Stability | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids, chloroformates. |
| CAS DataBase Reference | 99-55-8(CAS DataBase Reference) |
| IARC | 3 (Vol. 48) 1990 |
| NIST Chemistry Reference | Benzenamine, 2-methyl-5-nitro-(99-55-8) |
| EPA Substance Registry System | 2-Methyl-5-nitroaniline (99-55-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H351-H412 | |||||||||
| Precautionary statements | P201-P273-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 23/24/25-40-52/53 | |||||||||
| Safety Statements | 36/37-45-61 | |||||||||
| RIDADR | UN 2660 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XU8225000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214300 | |||||||||
| Toxicity | LD50 orl-rat: 574 mg/kg NCIMR* NIH-71-E-2144,73 | |||||||||
| NFPA 704 |
|
2-Methyl-5-nitroaniline price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M59386 | 2-Methyl-5-nitroaniline 98% | 99-55-8 | 100G | ₹4806.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 45984 | 2-Methyl-5-nitroaniline analytical standard | 99-55-8 | 100MG | ₹5217.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 402729 | 2-Methyl-5-nitroaniline 95% | 99-55-8 | 100G | ₹7209.45 | 2022-06-14 | Buy |
| ALFA India | ALF-A17726-36 | 2-Methyl-5-nitroaniline, 98+% | 99-55-8 | 500g | ₹6930 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0115 | 2-Methyl-5-nitroaniline min. 98.0 % | 99-55-8 | 25G | ₹3800 | 2022-05-26 | Buy |
2-Methyl-5-nitroaniline Chemical Properties,Uses,Production
Description
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and is an in vivo metabolic product of 2,4-dinitrotoluene. 
Uses
2-Methyl-5-nitroaniline may be employed as analytical standard for the surfactant mediated transformations (?254nm) of 2,4-dinitrotoluene.
Preparation
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
Definition
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
Preparation
o-Toluidine(500 mg, 4.19 mmol) was added with vigorous stirring to a balloon with concentrated sulfuric acid (3.9 ml, 71.4 mmol). The temperature of the reaction is 10 ℃ (salt/ice, cold bath). After that, an acid mixture (0.9 mlHNO3 and 0.9 ml H2SO4) was added to the solution for 2 h. The mixture was placed on ice and basified with NaOH. Finally, 2-methyl-5-nitroaniline was collected by filtration and washed with water.
Air & Water Reactions
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.
Reactivity Profile
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
Fire Hazard
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. Mutation data reported. Decomposes exothermically when heated to 150℃. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
Toxicology
Genetic toxicity studies for 2-methyl-5-nitroaniline indicate generally positive results in reverse-mutation assays in Salmonella typhimurium and Escherichia coli, and in Syrian hamster embryo (SHE) cell transformation assays; the compound is weaker in potency than other 2,4-dinitrotoluene metabolites.
Carcinogenicity
There are no data available for evaluating carcinogenic risk to humans. When 5-nitro-o-toluidine was administered in a dietary feeding study to F344 rats (50 or 100 ppm) and B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular carcinomas were produced in mice but not in rats.
Shipping
UN2660 Nitrotoluidines (mono), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
2-Methyl-5-nitroaniline Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| GRK RESEARCH LABORATORIES PVT LTD | +91-8249607014 +91-9849401944 | Hyderabad, India | 205 | 58 | Inquiry |
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| Monvi Labratories private limited | +91-40-29888025 +91-6303036807 | Telangana, India | 58 | 58 | Inquiry |
| JAY CHEMICALS | +91-9819633090 +91-9819633090 | Maharashtra, India | 85 | 58 | Inquiry |
| Bhagwati Industries | +91-9909249884 +91-9909249884 | Gujarat, India | 89 | 58 | Inquiry |
| DSN Labs | +91-4027152282 +91-9491052860 | Telangana, India | 30 | 58 | Inquiry |
| Vipul Organics Ltd | +91-2266139999 +91-2266139999 | Maharashtra, India | 277 | 58 | Inquiry |
| Moleculochem | 9811853366 | New Delhi, India | 25 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| GRK RESEARCH LABORATORIES PVT LTD | 58 |
| SVH BIOSCIENCES | 58 |
| Monvi Labratories private limited | 58 |
| JAY CHEMICALS | 58 |
| Bhagwati Industries | 58 |
| DSN Labs | 58 |
| Vipul Organics Ltd | 58 |
| Moleculochem | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |