2-メチル-5-ニトロアニリン 化学特性,用途語,生産方法
外観
暗黄色～黄褐色, 結晶性粉末～粉末
溶解性
水に難溶, エタノール, エーテル, アセトンに可溶。エタノールに溶け、水にほとんど溶けない。
用途
染料?顔料中間体 (化学工業日報社)
説明
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and is an in vivo metabolic product of 2,4-dinitrotoluene.
使用
2-Methyl-5-nitroaniline may be employed as analytical standard for the surfactant mediated transformations (?254nm) of 2,4-dinitrotoluene.
定義
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
製造方法
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
空気と水の反応
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.
反応プロフィール
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
火災危険
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.
安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic data.
Moderately toxic by ingestion. Mutation data
reported. Decomposes exothermically when
heated to 150℃. When heated to
decomposition it emits toxic fumes of NOx.
See also NITRO COMPOUNDS OF
AROMATIC HYDROCARBONS.
発がん性
There
are no data available for evaluating carcinogenic risk to
humans. When 5-nitro-o-toluidine was administered in a
dietary feeding study to F344 rats (50 or 100 ppm) and
B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular
carcinomas were produced in mice but not in rats.
輸送方法
UN2660 Nitrotoluidines (mono), Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
純化方法
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides;
chloroformates.
廃棄物の処理
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
2-メチル-5-ニトロアニリン 上流と下流の製品情報
原材料
準備製品