4,6-Dichloropyrimidine
- CAS No.
- 1193-21-1
- Chemical Name:
- 4,6-Dichloropyrimidine
- Synonyms
- NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
- CBNumber:
- CB6473590
- Molecular Formula:
- C4H2Cl2N2
- Molecular Weight:
- 148.98
- MOL File:
- 1193-21-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/14 18:24:50
| Melting point | 65-67 °C (lit.) |
|---|---|
| Boiling point | 176 °C (lit.) |
| Density | 1.6445 (rough estimate) |
| vapor pressure | 30-390Pa at 20-50℃ |
| refractive index | 1.6300 (estimate) |
| Flash point | 176°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow |
| pka | -4.20±0.17(Predicted) |
| form | Crystals |
| color | Yellow-green |
| BRN | 111195 |
| InChIKey | XJPZKYIHCLDXST-UHFFFAOYSA-N |
| LogP | 1.45 at 25℃ and pH7.2 |
| Surface tension | 65.72mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 1193-21-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrimidine, 4,6-dichloro-(1193-21-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-20/21/22-36/37 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
4,6-Dichloropyrimidine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 10G | ₹5131.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 50G | ₹16897.83 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D2488 | 4,6-Dichloropyrimidine min. 98.0 % | 1193-21-1 | 5G | ₹3100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D2488 | 4,6-Dichloropyrimidine min. 98.0 % | 1193-21-1 | 25G | ₹7700 | 2022-05-26 | Buy |
| ottokemi | D 3565 | 4,6-Dichloropyrimidine 98% | 1193-21-1 | 5gm | ₹2790 | 2022-05-26 | Buy |
4,6-Dichloropyrimidine Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.
General Description
Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.
Synthesis
The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.
4,6-Dichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Suven Pharmaceuticals Limited | +91-91-40-23541142 +91-4023541142 | Telangana, India | 218 | 58 | Inquiry |
| Nandana Laboratories Pvt. Ltd.(NLPL) | +91-8978635484 +91-6281929762 | Telangana, India | 40 | 58 | Inquiry |
| ARRKEM LIFE SCIENCES PRIVATE LIMITED | +91-8148739767 +91-8148739767 | Telangana, India | 347 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1878 | 58 | Inquiry |
| Madin Life Sciences Pvt Ltd | +91-9014759900 +91-9014759900 | Telangana, India | 230 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Chemphora life sciences | +91-9849979989 +91-9849979989 | Hyderabad, India | 326 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6202 | 58 | Inquiry |
| Survival Technologies Pvt Ltd | +91 (22) 4212-8221 | New Delhi, India | 290 | 50 | Inquiry |
| Avra Synthesis Pvt Ltd | +914027175796 | New Delhi, India | 1603 | 30 | Inquiry |
1193-21-1(4,6-Dichloropyrimidine)Related Search:
1of4
chevron_right