4,6-디클로로피리미딘
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4,6-디클로로피리미딘 속성
- 녹는점
- 65-67 °C (lit.)
- 끓는 점
- 176 °C (lit.)
- 밀도
- 1.6445 (rough estimate)
- 증기압
- 30-390Pa at 20-50℃
- 굴절률
- 1.6300 (estimate)
- 인화점
- 176°C
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- 95% 에탄올: 가용성 50mg/mL, 투명하거나 매우 약간 흐릿함, 무색 내지 노란색
- 산도 계수 (pKa)
- -4.20±0.17(Predicted)
- 물리적 상태
- 크리스탈
- 색상
- 연두색
- BRN
- 111195
- InChIKey
- XJPZKYIHCLDXST-UHFFFAOYSA-N
- LogP
- 1.45 at 25℃ and pH7.2
- 표면장력
- 65.72mN/m at 1g/L and 20℃
- CAS 데이터베이스
- 1193-21-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C | ||
---|---|---|---|
위험 카페고리 넘버 | 34-20/21/22-36/37 | ||
안전지침서 | 26-36/37/39-45-27 | ||
유엔번호(UN No.) | UN 3263 8/PG 2 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 19 | ||
위험 참고 사항 | Corrosive | ||
위험 등급 | 8 | ||
포장분류 | II | ||
HS 번호 | 29335990 | ||
기존화학 물질 | 2012-1-647 | ||
유해화학물질 필터링 | 2012-1-647 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 4,6-디클로로피리미딘 및 이를 25% 이상 함유한 혼합물 |
4,6-디클로로피리미딘 C화학적 특성, 용도, 생산
화학적 성질
Yellow Solid용도
4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.일반 설명
Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.Synthesis
The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.![synthesis of 4,6-Dichloropyrimidine synthesis of 4,6-Dichloropyrimidine](/NewsImg/2022-11-22/6380472479816732427549175.jpg)
4,6-디클로로피리미딘 준비 용품 및 원자재
원자재
준비 용품
에트림포스
벤설프론 메틸
2-Amino-4-Chloro-6-MethoxyPyrimidine
4,6-DIBROMOPYRIMIDINE
4-Hydroxy-6-aminopyrimidine
4-HYDRAZINO-6-HYDROXYPYRIMIDINE
클로리무론-에틸
2-아미노-4,6-디메톡시피리미딘
6-Chloropyrimidin-4(3H)-one
5-BROMO-4,6-DIMETHOXYPYRIMIDINE
4-Chloro-6-(1H-imidazol-1-yl)pyrimidine
4,6-DIFLUOROPYRIMIDINE
4-Chloro-6-thiophen-2-yl-pyrimidine
4-클로로-6-(사이클로프로필아미노)피리미딘
(6-클로로피리미딘-4-일)메탄광산
4,6-디클로로피리미딘 공급 업체
글로벌( 667)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 |
sales@whaop.com | China | 265 | 58 |
Golden Pharma Co., Limited | +undefined18958062155 |
sales@zjgoldpharm.com | China | 5905 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
4,6-디클로로피리미딘 관련 검색:
4,6-디클로로피리미딘
2-Amino-4-chloro-6-methoxypyrimidine
Methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate
4-Chloro-6-methyl-2-(methylthio)pyrimidine
5-amine-4,6-dichloropyrimidine,5-Amino-4,6-dichloropyrimidine, 98+%
4,6-Dichloro-5-nitropyrimidine
2-AMINO-4,6-DIHYDROXY-5-METHYLPYRIMIDINE
2,4,6-TRICHLORO-5-NITROPYRIMIDINE
4,6-Dichloro-2-methylpyrimidine
2-AMINO-4,6-DICHLOROPYRIMIDINE 95+%,2-AMINO-4,6-DICHLOROPYRIMIDINE 97+%
4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE
4,6-Dichloro-2-methyl-5-nitropyrimidine
2,4,6-Trichloro-5-methylpyrimidine
2,4,5,6-TETRACHLOROPYRIMIDINE
4,6-Dichloro-5-methoxypyrimidine
2,4-Dichloro-5-fluoropyrimidine
4,6-Dichloro-2-(methylthio)pyrimidine
2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride