IPI 145
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- Product name: IPI 145
- CAS: 1201438-56-3
- MF: C22H17ClN6O
- MW: 416.86
- EINECS:200-256-5
- MDL Number:MFCD15144635
- Synonyms:IPI-145;IPI-145 (INK-1197);IPI-145 INK197;8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone;IPI-145, >=98%;Duvelisib (IPI-145, INK1197);DUVELISIB (IPI-145);1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
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Properties
Melting point :205-206o C
Boiling point :757.8±60.0 °C(Predicted)
Density :1.474±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :White solid.
pka :10.05±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :757.8±60.0 °C(Predicted)
Density :1.474±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :White solid.
pka :10.05±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
IPI-145 is a potent inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms PI3Kγ and PI3Kδ (IC50s = 0.24 and 50 nM, respectively). It is orally bioavailable and selective. As PI3Kγ and PI3Kδ are preferentially expressed in immune cells, IPI-145 has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models. It also has potential applications in immunotherapy and in certain cancers.More related product prices
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