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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Oxaprozin

Oxaprozin

Oxaprozin Structure
  • ₹6700 - ₹20700
  • Product name: Oxaprozin
  • CAS: 21256-18-8
  • MF: C18H15NO3
  • MW: 293.32
  • EINECS:244-296-1
  • MDL Number:MFCD00215977
  • Synonyms:Dxaprozin;OXAPROZIN (3-(4,5-DIPHENYL-2-OXAZOLYL)PROPIONIC ACID);4,5-Diphenyl-2-oxazolepropanoic acid, Daypro;2-Oxazolepropanoic acid, 4,5-diphenyl-;Durapro;Oxapro;Oxaprozin (200 mg);3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid 97%
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberO0377
  • Product descriptionOxaprozin
  • Packaging5G
  • Price₹6700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberO0377
  • Product descriptionOxaprozin
  • Packaging25G
  • Price₹20700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO9637
  • Product descriptionOxaprozin solid
  • Packaging5MG
  • Price₹11950.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) O0377 Oxaprozin 5G ₹6700 2022-05-26 Buy
TCI Chemicals (India) O0377 Oxaprozin 25G ₹20700 2022-05-26 Buy
Sigma-Aldrich(India) O9637 Oxaprozin solid 5MG ₹11950.8 2022-06-14 Buy

Properties

Melting point :154 °C
Boiling point :435.17°C (rough estimate)
Density :1.2278 (rough estimate)
refractive index :1.5100 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO
form :solid
pka :4.3(at 25℃)
color :Crystals from methanol
Water Solubility :4mg/L(37 ºC)
Merck :14,6924
BCS Class :2
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :OFPXSFXSNFPTHF-UHFFFAOYSA-N
CAS DataBase Reference :21256-18-8(CAS DataBase Reference)
EPA Substance Registry System :2-Oxazolepropanoic acid, 4,5-diphenyl- (21256-18-8)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

Oxaprozin is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 in human synovial cells with IC50 values of 2.2 and 36 μM, respectively. It has been reported to inhibit thromboxane B2 production in human platelets (IC50 = ~2 μM) and to inhibit prostaglandin E2 production by human synovial cells stimulated with IL-1β (IC50 = ~20 μM). It demonstrates analgesic and anti-inflammatory activity in rodent models at doses of 70-100 mg/kg.

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