Oxaprozin
- CAS No.
- 21256-18-8
- Chemical Name:
- Oxaprozin
- Synonyms
- 3-(4,5-Diphenyloxazol-2-yl)propanoic acid;DAYPRO;3-(diphenyl-1,3-oxazol-2-yl)propanoic acid;Alvo;Oxapro;Durapro;Actirin;wy-21743;Oshapqin;Duraprost
- CBNumber:
- CB1272505
- Molecular Formula:
- C18H15NO3
- Molecular Weight:
- 293.32
- MOL File:
- 21256-18-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/19 15:37:50
| Melting point | 154 °C |
|---|---|
| Boiling point | 435.17°C (rough estimate) |
| Density | 1.2278 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 4.3(at 25℃) |
| color | Crystals from methanol |
| Water Solubility | 4mg/L(37 ºC) |
| Merck | 14,6924 |
| BCS Class | 2 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | OFPXSFXSNFPTHF-UHFFFAOYSA-N |
| CAS DataBase Reference | 21256-18-8(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Oxazolepropanoic acid, 4,5-diphenyl- (21256-18-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H413 |
| Precautionary statements | P501-P273 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-36/37/39-36-26 |
| WGK Germany | 3 |
| RTECS | RP6990000 |
| Hazard Note | Irritant |
| HS Code | 29349990 |
| Toxicity | TDLo orl-rbt: 39 mg/kg (female 6-18D post):TER IYKEDH 15,250,84 |
Oxaprozin price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O9637 | Oxaprozin solid | 21256-18-8 | 5MG | ₹11950.8 | 2022-06-14 | Buy |
| TCI Chemicals (India) | O0377 | Oxaprozin | 21256-18-8 | 5G | ₹6700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | O0377 | Oxaprozin | 21256-18-8 | 25G | ₹20700 | 2022-05-26 | Buy |
Oxaprozin Chemical Properties,Uses,Production
Description
Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long T1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3- substituted, rather than a 2-substituted propionic acid.
Chemical Properties
White Solid
Uses
Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).
Indications
Oxaprozin (Daypro) is approved for the treatment of osteoarthritis and rheumatoid arthritis. Its long halflife allows for once daily dosing.The most frequently reported adverse effects of this drug are nausea, vomiting, and dyspepsia.
Definition
ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit s and rheumatoid arthritis.
General Description
Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.
Pharmacokinetics
Oxaprozin is well absorbed (100%) following oral administration, but maximum plasma concentrations are not reached until 3 to 5 hours following ingestion. Oxaprozin is an anti-inflammatory agent possessing a rapid onset of action and a prolonged duration of action. In both the carrageenan raw paw edema assay and analgetic tests, it was equipotent with aspirin. Oxaprozin has been associated with the appearance of rash and/or mild photosensitivity. Some patients experience an increased incidence of rash on sun-exposed skin during clinical testing.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.
Oxaprozin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
| Anika International Pvt. Limited | 91-11-47289900 | Delhi, India | 94 | 58 | Inquiry |
| Athos Chemicals | 91-9998858909 | Gujarat, India | 315 | 58 | Inquiry |
| DR REDDYS LABORATORIES LTD | +91-40-49002900 | New Delhi, India | 201 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
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