Imipramine hydrochloride
- CAS No.
- 113-52-0
- Chemical Name:
- Imipramine hydrochloride
- Synonyms
- g22355;imidol;ia-pram;imavate;iprogen;tofranil;deprinol;dynazina;efuranol;fujisawa
- CBNumber:
- CB6698241
- Molecular Formula:
- C19H25ClN2
- Molecular Weight:
- 316.87
- MOL File:
- 113-52-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 168-1700C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | crystalline |
| color | white |
| PH | 4.2～5.2(100g/l,25℃) |
| Water Solubility | Soluble in water |
| λmax | 260nm(lit.) |
| Merck | 14,4920 |
| CAS DataBase Reference | 113-52-0(CAS DataBase Reference) |
| EPA Substance Registry System | 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 7-16-24-33-45-36-26-36/37 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HO1925000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2933995800 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe) | |||||||||
| NFPA 704 |
|
Imipramine hydrochloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I7379 | Imipramine hydrochloride ≥99% (TLC) | 113-52-0 | 5G | ₹10738.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1797 | Imipramine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 113-52-0 | 1G | ₹16053.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I7379 | Imipramine hydrochloride ≥99% (TLC) | 113-52-0 | 25G | ₹17482.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I-902 | Imipramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 113-52-0 | 1ML | ₹2407.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I7379 | Imipramine hydrochloride ≥99% (TLC) | 113-52-0 | 100G | ₹48247.03 | 2022-06-14 | Buy |
Imipramine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Imipramine hydrochloride is used as a serotonin uptake inhibitor. It mainly used in the treatment of major depression and enuresis (inability to control urination). It has also been evaluated for use in panic disorder.
General Description
Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D2 postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H1block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).
Clinical Use
The demethylated metabolite is less anticholinergic, lesssedative, and more stimulatory and is a SNERI.Consequently, a patient treated with imipramine has twocompounds that contribute to activity. Overall, the effect isnonselective 5-HT versus NE reuptake.
Safety Profile
Human poison by ingestion. An experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion: sleep, somnolence, convulsions, muscle contraction or spasticity, coma, blood pressure decrease, dyspnea (difficulty in breathing), paresthesia (abnormal sensations), and kidney changes. Experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also DIAZEPAM.
Imipramine hydrochloride Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SynThink RESEARCH CHEMICALS | +91-8177860948 +91-8177860948 | Mumbai, India | 494 | 58 | Inquiry |
| Maitree Research Pvt Ltd | +91-7926427200 +91-7926427200 | Gujarat, India | 19 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| Harika Drugs Pvt Ltd | +91-4023814863 +91-4023814863 | Telangana, India | 19 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Panchsheel Organics Limited | + 91 22 4345 4200 | Mumbai, India | 5 | 58 | Inquiry |
| Luconic Chemicals | 91-22-28704767 | Maharashtra, India | 72 | 58 | Inquiry |
| SPB Pharma Chiemimpex | 91-9043046289 | Tamil Nadu, India | 94 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SynThink RESEARCH CHEMICALS | 58 |
| Maitree Research Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| S D Fine Chem Limited | 58 |
| Molsyns Research | 58 |
| Harika Drugs Pvt Ltd | 58 |
| Pharma Affiliates | 58 |
| Panchsheel Organics Limited | 58 |
| Luconic Chemicals | 58 |
| SPB Pharma Chiemimpex | 58 |