ChemicalBook > Product Catalog >API >Nervous system drugs >Antidepressants, Antimanics drugs >IMIPRAMINE
IMIPRAMINE
- CAS No.
- 50-49-7
- Chemical Name:
- IMIPRAMINE
- Synonyms
- IM;DPID;Irmin;Iramil;Imizin;Imiprin;Imizine;Surplix;Timolet;Censtim
- CBNumber:
- CB1727489
- Molecular Formula:
- C19H24N2
- Molecular Weight:
- 280.41
- MOL File:
- 50-49-7.mol
- Modify Date:
- 2024/7/2 8:55:01
| Melting point | 174°C |
|---|---|
| Boiling point | bp0.1 160° |
| Density | 0.9935 (rough estimate) |
| refractive index | 1.5640 (estimate) |
| pka | pKa 9.66(H2O,t = 25,I=0.025) (Uncertain) |
| form | Liquid |
| color | Colorless to light yellow |
| Water Solubility | 18.23mg/L(24 ºC) |
| Solvent | Ethanol under nitrogen |
| Concentration | 1 mCi/ml |
| Specific Activity | 60-90 Ci/mmol |
| BCS Class | 1 |
| EPA Substance Registry System | Imipramine (50-49-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H336-H370-H400 |
| Precautionary statements | P261-P280-P305+P351+P338-P304+P340-P271-P312-P405-P403+P233-P260-P264-P270-P307+P311-P321-P405-P501-P391 |
| Toxicity | A tertiary amine tricyclic antidepressant that is thought to exert its therapeutic effect by inhibiting the reuptake of serotonin and norepinephrine centrally. A major metabolite is N-desmethylimipramine (desipramine), also used as an antidepressant drug. Desipramine differs from imipramine in being a better blocker of norepinephrine, rather than serotonin, uptake. Side effects, including sedation and drowsiness, dry mouth, urinary retention, constipation, and orthostatic hypotension, are probably due to the anticholinergic, anti-α-adrenergic, and antihistaminergic receptor-blocking properties. Imipramine should not be used in conjunction with a monoamine oxidase inhibitor or other treatment that increases catecholamine concentrations (e.g., drugs containing sympathomimetic amines). Imipramine should be avoided in patients with cardiovascular disease or seizure disorder, or in those who may abuse alcohol, as imipramine lowers seizure threshold, can produce cardiovascular toxicity and may potentiate the effects of alcohol. Imipramine intoxication can include CNS abnormalities (e.g., drowsiness, stupor, coma, and extrapyramidal symptoms), cardiac arrhythmia, and respiratory depression. Children appear to be particularly vulnerable to the cardiotoxic and seizure-inducing effects of high doses of imipramine. The oral LD50 in female rats is 305 mg/kg. |
IMIPRAMINE Chemical Properties,Uses,Production
Uses
Imipramine is used in depression of various etiology accompanied by motor clumsiness and enuresis in children and Parkinson’s disease.
Mechanism of action
Besides being used in the clinical treatment of depression, imipramine also has been used for the treatment of functional enuresis in children who are at least 6 years of age (25 mg daily administered 1 hour before bedtime, not to exceed 2.5 mg/kg daily).
Clinical Use
Imipramine is a 10,11-dihydrodibenzazepine tertiary amine TCA that is marketed as hydrochloride and pamoate salts, both of which are administered orally. Although the hydrochloride salt may be administered in divided daily doses, imipramine's long duration of action suggests that the entire oral daily dose may be administered at one time.On the other hand, imipramine pamoate usually is administered as a single daily oral dose.
IMIPRAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 69)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Ariheet Pharmachem Llp | 08048951948 | Mumbai, India | 22 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21673 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
50-49-7(IMIPRAMINE)Related Search:
IM
Imidobenzyle
Imipramina
Imiprin
Imizin
Imizine
Imizinum
Impramine
Intalpram
Iramil
Irmin
Melipramin
Melipramine
N-(3-Dimethylaminopropyl)-o-iminodibenzyl
N-(gamma-Dimethylaminopropyl)iminodibenzyl
Nelipramin
Prazepine
Promiben
Psychoforin
SK-Pramine
Surplix
Timolet
Tofranil (free base)
Tofranil, base
Tofraniln A
3-(10,11-dihydrodibenz(b,f)azepin-5-yl)propyldimethylamine
N-[γ-Dimethylaminopropyl] iminodibenzyl
IMIPRAMINE,1.0MG/MLINMETHANOL
IMIPRAMINE
AURORA KA-7708
1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine
10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine
2,2'-(3-Dimethylaminopropylimino)bibenzyl
2,2'-(3-Dimethylaminopropylimino)dibenzyl
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-
5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
Antideprin
Berkomine
Censtim
Censtin
Declomipramine
Dimipressin
DPID
Dynaprin
Eupramin
Imipramine (base and/or unspecified salts)
N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-(1-propanamine)
3-(4a,5-dihydro-4H-dibenzo[b,f]azepin-10-yl)-N,N-diMethylpropan-1-aMine
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Clomipramine HCl EP Impurity B
Trimipramine BP Impurity D
Imipramine for system suitability CRS
Imipramine (Clomipramine EP Impurity B)