Clomipramine
![Clomipramine Structure](CAS/GIF/303-49-1.gif)
- CAS No.
- 303-49-1
- Chemical Name:
- Clomipramine
- Synonyms
- CLOMIPRAMINE HCL;ANAFRANIL;CHLORIMIPRAMINE;CIM;g34586;G34596;5H-Dibe;G 34586;Hydiphen;CLOMIPRAMINE
- CBNumber:
- CB5173107
- Molecular Formula:
- C19H23ClN2
- Molecular Weight:
- 314.85
- MOL File:
- 303-49-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 16:42:00
Melting point | 189.5°C |
---|---|
Boiling point | bp0.3 160-170° |
Density | 1.0568 (rough estimate) |
refractive index | 1.5749 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | H2O: 25 mg/mL |
form | powder |
pka | pKa 9.38(H2O) (Uncertain) |
color | white to off-white |
CAS DataBase Reference | 303-49-1(CAS DataBase Reference) |
NIST Chemistry Reference | Clomipramine(303-49-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS07,GHS08,GHS09 |
---|---|
Signal word | Danger |
Hazard statements | H410-H302-H370-H336 |
Precautionary statements | P260-P264-P270-P307+P311-P321-P405-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501-P273-P391-P501 |
Hazard Codes | Xn |
Risk Statements | 20/21/22 |
Safety Statements | 36 |
WGK Germany | 3 |
RTECS | HN9055000 |
Clomipramine Chemical Properties,Uses,Production
Uses
Antidepressan.
Definition
ChEBI: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressan s, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Mechanism of action
Clomipramine is different from the other TCAs, exhibiting preferential selectivity for inhibiting the reuptake of
5-HT at the presynaptic neuronal membrane. Its antidepressant mechanism of action as an inhibitor of the
5-HT transporter is reduced in vivo, however, because of the formation of its active metabolite,
N-desmethylclomipramine, which inhibits the reuptake of NE. As a result of its common structure with the
other TCAs, clomipramine shares the pharmacological and adverse-effect profile of the other TCAs.
The efficacy of clomipramine relative to the other TCAs in the treatment of obsessive-compulsive disorder
may be related to its potency in blocking 5-HT reuptake at the presynaptic neuronal membrane, suggesting a
dysregulation of 5-HT for the pathogenesis of obsessive-compulsive disorder. Clomipramine appears to
decrease the turnover of 5-HT in the CNS, probably because of a decrease in the release and/or synthesis of
5-HT.
Although in vitro studies suggest that clomipramine is approximately four times more potent than fluoxetine as
a 5-HT reuptake inhibitor, in vivo studies suggest the opposite. This difference has been attributed to the
relatively long elimination half-lives for fluoxetine and its principal serotonergic metabolite norfluoxetine. In
addition, metabolism of clomipramine to its N-desmethyl secondary amine metabolite decreases the potency
and selectivity of 5-HT -reuptake inhibition of clomipramine, but not fluoxetine.
Clinical Use
Clomipramine is considered to be the most powerful antidepressant ever made. This dihydrodibenzazepine TCA, with actions on both the NE and 5-HT transporters, was the last of the major TCAs to come to market. Initially, the U.S. FDA regarded it as another “me-too” drug, and accordingly, they did not license it. Subsequently, however, it was licensed for the treatment of obsessive-compulsive disorders. Clomipramine differs from imipramine only by the addition of a 3-chloro group.
Side effects
Male patients taking clomipramine should be informed of sexual dysfunction as a side effect associated with antidepressants having significant serotonergic activity. Sexual dysfunction in men appears as ejaculatory incompetence, ejaculatory retardation, decreased libido, or inability to obtain or maintain an erection. Sexual dysfunction is dose-related and may be treated by simply lowering the drug dose.
Clomipramine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Sibram Pharmaceutical | +91-8655777550 +91-8655777550 | Maharashtra, India | 244 | 58 | Inquiry |
OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
SOLARA ACTIVE PHARMA SCIENCES LTD | +91 44 4344 6700 | New Delhi, India | 89 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
MANGALAM DRUGS AND ORGANICS LIMITED | 08147509329 | Uttar Pradesh, India | 50 | 58 | Inquiry |
Mahir Technologies Inc. | 09930610606 | Mumbai, India | 38 | 58 | Inquiry |
Apex Distributors | 08048372628Ext 317 | Mumbai, India | 14 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
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