Chlordiazepoxide
- CAS No.
- 58-25-3
- Chemical Name:
- Chlordiazepoxide
- Synonyms
- ocm;Librax;Solium;Risolid;LIBRIUM;Control;CHLORDIAZEPOXIDE BASE;7-Cloro-2-metilamino-5-fenil-3H-1,4-benzodiazepina 4-ossido;3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide;Eden
- CBNumber:
- CB2409270
- Molecular Formula:
- C16H14ClN3O
- Molecular Weight:
- 299.75
- MOL File:
- 58-25-3.mol
- Modify Date:
- 2023/6/8 9:02:13
| Melting point | 230-232°C |
|---|---|
| Boiling point | 549.0±60.0 °C(Predicted) |
| Density | 1.2967 (rough estimate) |
| refractive index | 1.6490 (estimate) |
| Flash point | 9℃ |
| storage temp. | Controlled Substance, -20°C Freezer, Under Inert Atmosphere |
| solubility | Practically insoluble in water, sparingly soluble in ethanol (96 per cent) |
| pka | 4.8(at 25℃) |
| form | A crystalline solid |
| Water Solubility | 2g/L(room temperature) |
| CAS DataBase Reference | 58-25-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzodiazepine-4-oxide, 7-chloro-2-methylamino-5-phenyl-3h-1,4-(58-25-3) |
| EPA Substance Registry System | Chlordiazepoxide (58-25-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 1 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933910000 | |||||||||
| Toxicity | LD50 oral in rabbit: 590mg/kg | |||||||||
| NFPA 704 |
|
Chlordiazepoxide Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics
Definition
ChEBI: A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
Hazard
Anticonvulsant, sedative, and amnesic properties.
Metabolism
Chlordiazepoxide is well absorbed after oral administration, and peak blood concentration usually is reached in approximately 4 hours. Intramuscular absorption of chlordiazepoxide, however, is slower and erratic. The half-life of chlordiazepoxide is variable but usually quite long (6–30 hours). The initial N-demethylation product, N-desmethylchloridiazepoxide, undergoes deamination to form the demoxepam, which is extensively metabolized, and less than 1% of a dose of chlordiazepoxide is excreted as demoxepam. Demoxepam can undergo four different metabolic fates. Removal of the N-oxide moiety yields the active metabolite, N-desmethyldiazepam (desoxydemoxepam). This product is a metabolite of both chlordiazepoxide and diazepam and can be hydroxylated to yield oxazepam, another active metabolite that is rapidly glucuronidated and excreted in the urine. Another possibility for metabolism of demoxepam is hydrolysis to the “opened lactam,” which is inactive. The two other metabolites of demoxepam are the products of ring A hydroxylation (9-hydroxydemoxepam) or ring C hydroxylation (4′-hydroxydemoxepam), both of which are inactive.
Chlordiazepoxide Preparation Products And Raw materials
Raw materials
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