Clomipramine hydrochloride
- CAS No.
- 17321-77-6
- Chemical Name:
- Clomipramine hydrochloride
- Synonyms
- ANAFRANIL;Clomicalm;anaphranil;Chlomipramine;CLOMIPRAMINE HCL;Clomipramine hydroch;Chloroimipram-ine HCl;ANAFRANIL HYDROCHLORIDE;Clomipraminhydrochlorid;Clomipramine-13C-d3 HCl
- CBNumber:
- CB2173106
- Molecular Formula:
- C19H24Cl2N2
- Molecular Weight:
- 351.31
- MOL File:
- 17321-77-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 16:18:34
| Melting point | 189-190°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 25 mg/mL |
| form | powder |
| color | white to off-white |
| PH | 3.5～5.0（100g/l，25℃） |
| BCS Class | 3/1 |
| InChIKey | WIMWMKZEIBHDTH-UHFFFAOYSA-N |
| CAS DataBase Reference | 17321-77-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H336-H370-H410 | |||||||||
| Precautionary statements | P260-P264-P270-P273-P301+P312-P308+P311 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/21/22-39/23/24/25-23/24/25-11-36/37/38 | |||||||||
| Safety Statements | 36-45-36/37-16-7-62-38-36/37/39-28-26-24/25-22-20/21-13 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HN9055000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933996100 | |||||||||
| NFPA 704 |
|
Clomipramine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C7291 | Clomipramine hydrochloride ≥98% (HPLC), powder | 17321-77-6 | 1G | ₹4514.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1720 | Clomipramine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 17321-77-6 | 1G | ₹15934.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7291 | Clomipramine hydrochloride ≥98% (HPLC), powder | 17321-77-6 | 5G | ₹17698.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C-118 | Clomipramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 17321-77-6 | 1ML | ₹2407.3 | 2022-06-14 | Buy |
Clomipramine hydrochloride Chemical Properties,Uses,Production
Description
Clomipramine is a tricyclic antidepressant, the 3-
Chemical Properties
Off-White Solid
Uses
Serotonin reuptake inhibitor. Antidepressant; antiobsessional agent
Definition
ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of clomipramine and hydrogen chloride. One of the more sedating tricyclic antidepressants, it is used for the treatment of depression as well as obsessive-compulsive disorder and phobias.
General Description
Clomipramine (Anafranil) is up to 50 times as potentas imipramine in some bioassays. This does not implyclinical superiority, but it might be informative about tricyclicand, possibly, other reuptake inhibitors. The chloro replacingthe H-substituent could increase potency by increasingdistribution to the CNS, but it is unlikely that this wouldgive the potency magnitude seen. It might be conjecturedthat an H-bond between the protonated amino group (as invivo) and the unshared electrons of the chloro substituent might stabilize a β-arylamine–like shape and give moreefficient competition for the transporter. The drug is anantidepressant. It is used in obsessive–compulsive disorder,an anxiety disorder that may have an element of depression.
Biological Activity
Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a K i of 0.05 nmol/l. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .
Clomipramine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SKVen Technologies Pvt.Ltd. | +91-7032295152 +91-7032295152 | Hyderabad, India | 81 | 58 | Inquiry |
| Global Pharma | +91-9819994077 +91-9819994077 | Maharashtra, India | 34 | 58 | Inquiry |
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Mankind Pharma Limited | +91-1146541111 +91-1146541111 | New Delhi, India | 23 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Almon Industries | +91-9909010480 +91-9898908297 | Gujarat, India | 12 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| Flowchem Pharma Pvt Ltd | +91-9606036218 +91-9845055636 | Karnataka, India | 33 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SKVen Technologies Pvt.Ltd. | 58 |
| Global Pharma | 58 |
| R L Fine Chem Pvt. Ltd | 58 |
| Mankind Pharma Limited | 58 |
| Sun Pharmaceutical Industries Ltd | 58 |
| Almon Industries | 58 |
| Ralington Pharma | 58 |
| Biophore India Pharmaceuticals Pvt Ltd | 58 |
| Molsyns Research | 58 |
| Flowchem Pharma Pvt Ltd | 58 |