QUINACRINE DIHYDROCHLORIDE
- CAS No.
- 69-05-6
- Chemical Name:
- QUINACRINE DIHYDROCHLORIDE
- Synonyms
- QUINACRINE;MEPACRINE;ATABRINE;sn390;erion;mecryl;866r.p.;palusan;erionHCl;italchin
- CBNumber:
- CB8320579
- Molecular Formula:
- C23H32Cl3N3O
- Molecular Weight:
- 472.88
- MOL File:
- 69-05-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:16
| Melting point | 249-251℃ (Decomposition) |
|---|---|
| Density | 1.2962 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | +15C to +30C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) |
| form | Yellow solid |
| pka | pKa -6.3(H2O t undefined I not reported but low) (Uncertain) |
| color | Light Yellow to Yellow |
| PH | 3.0～5.0 (20g/l, 25℃) |
| Water Solubility | Water: 33.33 mg/mL (70.48 mM) |
| Merck | 14,8044 |
| BRN | 4834013 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| EPA Substance Registry System | Quinacrine hydrochloride (69-05-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 36/37/39 |
| WGK Germany | 3 |
| RTECS | AR7875000 |
| Toxicity | LD50 oral in rabbit: 433mg/kg |
QUINACRINE DIHYDROCHLORIDE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | Q3251 | Quinacrine dihydrochloride ≥90% | 69-05-6 | 25G | ₹13497.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Q3251 | Quinacrine dihydrochloride ≥90% | 69-05-6 | 100G | ₹37051.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 551850 | Quinacrine dihydrochloride A non-specific phospholipase A2 (PLA2) inhibitor. | 69-05-6 | 100MG | ₹7070 | 2022-06-14 | Buy |
| ottokemi | Q 1220 | Quinacrine hydrochloride, 90% | 69-05-6 | 5gm | ₹3969 | 2022-05-26 | Buy |
| ottokemi | Q 1220 | Quinacrine hydrochloride, 90% | 69-05-6 | 25gm | ₹12006 | 2022-05-26 | Buy |
QUINACRINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
yellow crystals or powder
Uses
Quinacrine dihydrochloride has been used:
- in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
- in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
- in uptake-release assay for characterization of dense granule functionality of platelets
Indications
Quinacrine is no longer used extensively as an antimalarial drug and has been largely replaced by the 4- aminoquinolines.
Antimicrobial activity
Mepacrine is active against the asexual erythrocytic stage of all four Plasmodium spp. that infect humans and the gametocytes of P. vivax and P. malariae. The enantiomers have equal antimalarial activity. It exhibits broad activity in experimental models against T. cruzi, Leishmania spp., E. histolytica, Trichomonas vaginalis, G. lamblia and Blastocystis hominis. It is also active against tapeworms.
Acquired resistance
The structural resemblance to chloroquine suggests the likelihood of cross-resistance with that drug, but evidence for this is equivocal.
General Description
Bright yellowish needles or bright yellow powder. Odorless. pH of a 1% aqueous solution is about 4.5.. Used as an anti-malarial drug. Moderately toxic.
Air & Water Reactions
Water soluble.
Reactivity Profile
QUINACRINE DIHYDROCHLORIDE is an acidic salt of an amine. React as a weak acid to neutralize bases.
Fire Hazard
Flash point data for QUINACRINE DIHYDROCHLORIDE are not available, but QUINACRINE DIHYDROCHLORIDE is probably combustible.
Pharmaceutical Applications
A synthetic acridine derivative, formulated as the hydrochloride for oral use.
Pharmacokinetics
Oral absorption: Good
Cmax 100 mg oral: 50 μg/L after 1–3 h
Plasma half-life: 5 days
Plasma protein binding: 85%
There is extensive tissue binding and a six-fold concentration into
leukocytes from plasma. About 10% of the daily dose is excreted
in the urine. It is widely distributed throughout the body.
Clinical Use
Giardiasis
Prophylaxis of malaria
Tapeworm infections
Side effects
Dizziness, headache and gastric problems are common. Toxic psychoses, bone marrow depression, yellow skin and exfoliative dermatitis are described. Poor toleration is noted, especially in children. It should not be used in combination with 8-aminoquinolines.
Purification Methods
It crystallises from H2O (solubility is 2.8% at room temperature) as yellow crystals. It is slightly soluble in MeOH and EtOH. The free base crystallises from Me2CO or pet ether with m 86-88o, or aqueous EtOH with 85-87.5o. The bismethiodide has m 224o (from MeOH/EtOAc/Et3N), and the picrate has m 207-208o(dec) when crystallised from Me2CO/EtOH. It is an antimalarial, antiprotozoal and intercalates DNA. [Wolfe Antibiot 3 (Springer-Verlag) 203 1975, Beilstein 22 III/IV 6247, 22/12 V 235.]
QUINACRINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Dolace Solutions Private Limited | 91--9890007892 | Maharashtra, India | 240 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |