Cetirizine dihydrochloride
- CAS No.
- 83881-52-1
- Chemical Name:
- Cetirizine dihydrochloride
- Synonyms
- CETIRIZINE DIHYDROCHLORIDE;CETIRIZINE HCL;CETIRIZINE 2HCL;ZYRTEC;CETIRIZINE DI HCL;Triz;Certirizine;CETIRIZIN DIHYDROCHLORIDE;Cesta;Ryzen
- CBNumber:
- CB6135030
- Molecular Formula:
- C21H26Cl2N2O3
- Molecular Weight:
- 425.35
- MOL File:
- 83881-52-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 13:33:21
| Melting point | 110-115°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL, clear |
| form | powder |
| color | white to beige |
| Water Solubility | Soluble in water, DMSO, ethanol, and methanol. |
| Merck | 14,2022 |
| BCS Class | 1,3 |
| Stability | Hygroscopic |
| InChIKey | PGLIUCLTXOYQMV-UHFFFAOYSA-N |
| CAS DataBase Reference | 83881-52-1(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) (83881-52-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AG0977500 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Cetirizine dihydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C3618 | Cetirizine dihydrochloride ≥98% (HPLC) | 83881-52-1 | 50MG | ₹5856.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1656 | Cetirizine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 83881-52-1 | 1G | ₹9818.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3618 | Cetirizine dihydrochloride ≥98% (HPLC) | 83881-52-1 | 250MG | ₹26304.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 89126 | Cetirizin dihydrochloride ≥98.0% (HPLC) | 83881-52-1 | 50MG | ₹3648.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 89126 | Cetirizin dihydrochloride ≥98.0% (HPLC) | 83881-52-1 | 1G | ₹3994.43 | 2022-06-14 | Buy |
Cetirizine dihydrochloride Chemical Properties,Uses,Production
Description
Cetirizine hydrochloride is a once-daily, non-sedating antihistamine useful in the treatment of allergic rhinitis, urticaria and conjunctivitis. It is reported to be more effective than most other agents in this category such as terfenadine and astemizole.
Chemical Properties
Cetirizine Hydrochloride occurs as a white crystalline powder or crystalline solid. It is very soluble in water, and slightly soluble in ethanol (99.5). It dissolves in 0.1 mol/L hydrochloric acid TS. A solution of Cetirizine Hydrochloride (1 in 10) shows no optical rotation.
Application
Cetirizine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Uses
Cetirizine hydrochloride is a nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. It is Cetirizine is an antihistamine medicine that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
Indications
Cetirizine HCl (Zyrtec) is the carboxylic acid metabolite of hydroxyzine. It is a selective, peripheral H1 receptor antagonist. It is a long-lasting antihistamine. It does not appear to have the same adverse cardiac effects as the other nonsedating H1 antihistamines; however, additional data are required. Indicated for allergic rhinitis and chronic urticaria.
General Description
Cetirizine hydrochloride, a second generation antihistaminic drug, is one of the carboxylated metabolites of hydroxyzine that can typically bind to histamine H1 receptor. It is effective against diseases such as urticaria, angioedema, allergies and hay fever.
Biological Activity
Histamine H 1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μ M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo .
Side effects
There are many side effects of Cetirizine hydrochloride which can be classified into five levels including common side effects (10%), more common side effects (1%), rare side effects (0.1%), very rare side effects (0.01%) and other side effects.
Common side effects include: drowsiness, dizziness, headache, pharyngitis, rhinitis (children), diarrhoea (children), nausea, dry mouth, fatigue. More common side effects include: restlessness, paresthesia (tingling or numbness in the hands and feet), diarrhoea, stomach pain, pruritus (itching), rash, asthenia (unusual weakness), weakness.
Rare side effects include: hypersensitivity, aggression, confusion, depression, hallucinations, insomnia, convulsions, tachycardia (fast heartbeat), abnormal liver function, hives, oedema (swelling), weight gain. Very rare side effects: Thrombocytopenia (low platelet count), anaphylaxis, convulsions (uncontrolled body movements), gustatory disturbances (disturbances in taste or loss of taste), dyskinesia (dyskinesia (uncontrolled movements), dystonia (uncontrolled muscle spasms), syncope (fainting), ophthalmoplegia (uncontrolled circular movements of the eyes), angioedema (severe). allergic reaction that causes swelling of the face or throat), dysuria (pain when urinating), incontinence (bedwetting).
Other side effects include: increased appetite, suicidal thoughts, nightmares, amnesia, memory problems, dizziness (spinning sensation), inflammation of the liver, urinary retention (difficulty in urinating), pain in the joints, rash with pus-containing blisters, and severe itching after stopping the drug (pruritus).
Cetirizine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| ALMELO PRIVATE LIMITED | +91-9100991345 +91-8500807769 | Telangana, India | 114 | 58 | Inquiry |
| Enzal Chemicals India Limited | +91-9930897773 +91-9930897773 | New Delhi, India | 25 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| KARUNESH REMEDIES | +919998776849 | Gujarat, India | 18 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| ALMELO PRIVATE LIMITED | 58 |
| Enzal Chemicals India Limited | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| HEMA PHARMACEUTICALS PVT LTD | 58 |
| THE MOLECULEZ | 58 |
| Frolic Pharmachem | 58 |
| AnalyticsStanza Inc | 58 |
| Gonane Pharma | 58 |
| KARUNESH REMEDIES | 58 |
Related Qustion
- Q:Can you take Mucinex with zyrtec？
- A:Zyrtec is a second-generation antihistamine and typically provides 24-hour coverage for allergic symptoms such as a runny nose....
- Mar 4，2024
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