Cetirizine
- CAS No.
- 83881-51-0
- Chemical Name:
- Cetirizine
- Synonyms
- CETIRIZINE LACTOSE ESTER;vidix;P-071;Zyrlex;Zirtek;Reactine;Formistin;Ceterizine;CETIRIZINE;CETIRIZINE BASE
- CBNumber:
- CB3440625
- Molecular Formula:
- C21H25ClN2O3
- Molecular Weight:
- 388.89
- MOL File:
- 83881-51-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 110-115°C |
|---|---|
| Boiling point | 542.1±45.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | insoluble in EtOH; ≥122 mg/mL in H2O; ≥19.44 mg/mL in DMSO |
| form | solid |
| pka | 3.46±0.10(Predicted) |
| color | Off-white to light yellow |
| Water Solubility | 101 mg/L |
| CAS DataBase Reference | 83881-51-0(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (83881-51-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | AG0977500 |
Cetirizine Chemical Properties,Uses,Production
Chemical Properties
white, crystalline powder
Uses
Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.
Definition
ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
General Description
Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Clinical Use
Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.
Cetirizine Preparation Products And Raw materials
Raw materials
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