ChemicalBook > Product Catalog >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Nimesulide
Nimesulide
- CAS No.
- 51803-78-2
- Chemical Name:
- Nimesulide
- Synonyms
- Nimesulide-d5;N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE;Nide;Nidol;nimed;AULIN;R-805;Aufin;Nisuli;MESULID
- CBNumber:
- CB0138084
- Molecular Formula:
- C13H12N2O5S
- Molecular Weight:
- 308.31
- MOL File:
- 51803-78-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:54:56
| Melting point | 140-146°C |
|---|---|
| Boiling point | 442.0±55.0 °C(Predicted) |
| Density | 1.451±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol. |
| form | Solid |
| pka | pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate) |
| color | Light orange to Yellow to Green |
| Water Solubility | Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH. |
| λmax | 391nm(H2O)(lit.) |
| Merck | 14,6548 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
| CAS DataBase Reference | 51803-78-2(CAS DataBase Reference) |
| EPA Substance Registry System | Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PB0970000 | |||||||||
| HS Code | 2935.90.9500 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 orally in rats: 324 mg/kg (Swingle, Moore) | |||||||||
| NFPA 704 |
|
Nimesulide price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N1016 | Nimesulide | 51803-78-2 | 1G | ₹3085.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1336 | Nimesulide Pharmaceutical Secondary Standard; Certified Reference Material | 51803-78-2 | 1G | ₹8919.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N1016 | Nimesulide | 51803-78-2 | 5G | ₹9959 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N1016 | Nimesulide | 51803-78-2 | 25G | ₹32648.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0984 | Nimesulide | 51803-78-2 | 1G | ₹2200 | 2022-05-26 | Buy |
Nimesulide Chemical Properties,Uses,Production
Description
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Chemical Properties
Yellow Needle-Like Crystals
Uses
Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.
General Description
Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.
Clinical Use
Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.
References
https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743
Nimesulide Preparation Products And Raw materials
Raw materials
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Global( 560)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Shiv pharma chem | +91-9974421207 +91-9974421207 | Gujarat, India | 52 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Meenaakshi Molecules Pvt Ltd | +91-9121311126 +91-9121311126 | Telangana, India | 45 | 58 | Inquiry |
| Globus Pharmachem (Para Products Pvt Ltd) | +91-1204198900 +91-9899370547 | Uttar Pradesh, India | 22 | 58 | Inquiry |
| Smaart Pharmaceutticals | +91-9970380295 +91-9970380295 | Maharashtra, India | 9 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| NB Healthcare Pvt Ltd | 58 |
| THE MOLECULEZ | 58 |
| Shiv pharma chem | 58 |
| AARTIA KEM SCIENCE | 58 |
| Gonane Pharma | 58 |
| Medi Pharma Drug House | 58 |
| Meenaakshi Molecules Pvt Ltd | 58 |
| Globus Pharmachem (Para Products Pvt Ltd) | 58 |
| Smaart Pharmaceutticals | 58 |
| Bajaj Healthcare Ltd | 58 |
51803-78-2(Nimesulide)Related Search:
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nimed
4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE
CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD)
CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHOXY]ETHOXY]ACETIC ACID MM(CRM STANDARD)
CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD)
4-Nitro-2-phenoxymethanesulfonamide
Nide
Nidol
Nisuli
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-
N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE(NIMESULIDE)
MESULID
AULIN
FANSIDOL
Nimesulide,N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Nimesulide for peak identification
Lizepat
4-Nitro-2-(phenoxy-d5)
MethanesulfonaMide-d5
4'-Nitro-2'-(phenoxy-d5)Methanesulfonanilide
Aulin-d5
Flogovital-d5
Lizepat-d5
N-(4-Nitro-2-(phenoxy-d5)phenyl)MethanesulfonaMide
sulidene
Nisulid
N-(4-NITRO-2-PHENOXY)METHANESULFONANILIDE
NIMESULIDE
R-805
4’-nitro-2’-phenoxy-methanesulfonanilid
4-nitro-2-phenoxy-methanesulfonanilide
flogovital
n-(4-nitro-2-phenoxyphenyl)-methanesulfonamid
Aufin
N-(4-Nitro-2-phenoxyphenyl)methanesulphonamide
Nimesulide >
Nimesulide for peak identification CRS
Nimesulide CRS
Nimesulide USP/EP/BP
Nimesulide (R805)
Nimesulli
Nimesulide, GR
Nimesulide (N0845000)
Nimesulide for peak identification (Y0001237)
NimesulideQ: What is
Nimesulide Q: What is the CAS Number of
Nimesulide Q: What is the storage condition of
Nimesulide
N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE
Nimesulide-d5
MESULID Powder USP Standard
nimesulin
Nimesulide
(BP)
4'-Hydroxy Nimesulide-d4
51803-78-2
C13H7N2O5SD5
C13H7D5N2O5S
Cell Signaling Enzymes
BioChemical
Application Index
Biochemicals and Reagents
Cyclooxygenase (COX) Enzymes