ChemicalBook > Product Catalog >Organic Chemistry >Ethers and derivatives >Ethers, ether-alcohols, ether phenol derivatives >2-Methoxy-4-nitroaniline

2-Methoxy-4-nitroaniline

2-Methoxy-4-nitroaniline Structure
CAS No.
97-52-9
Chemical Name:
2-Methoxy-4-nitroaniline
Synonyms
FAST RED B BASE;FAST RED B;RED B BASE;2-AMINO-5-NITROANISOLE;RED B ASE;METHOXY-4-NITROANILINE;4-NITRO-ORTHO-ANISIDINE;AZOIC DIAZO COMPONENT 5;4-NITRO-2-METHOXYANILINE;2-Methoxy-4-nitrobenzenamine
CBNumber:
CB1693973
Molecular Formula:
C7H8N2O3
Molecular Weight:
168.15
MOL File:
97-52-9.mol
MSDS File:
SDS
Modify Date:
2023/9/21 10:07:12

2-Methoxy-4-nitroaniline Properties

Melting point 140-142 °C(lit.)
Boiling point 337.07°C (rough estimate)
Density 1,211 g/cm3
refractive index 1.6010 (estimate)
storage temp. Store below +30°C.
solubility 0.2g/l
pka 1.02±0.10(Predicted)
form Crystalline Powder
color Yellow to orange
PH 6.2 (0.2g/l, H2O, 20℃)
Water Solubility slightly soluble
BRN 879619
InChIKey GVBHRNIWBGTNQA-UHFFFAOYSA-N
CAS DataBase Reference 97-52-9(CAS DataBase Reference)
NIST Chemistry Reference Benzenamine, 2-methoxy-4-nitro-(97-52-9)
EPA Substance Registry System 2-Methoxy-4-nitroaniline (97-52-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H302-H351-H411
Precautionary statements  P202-P264-P270-P273-P301+P312-P308+P313
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-37/39-36/37
RIDADR  UN 3077 9 / PGIII
WGK Germany  2
RTECS  BZ7170000
Hazard Note  Irritant
TSCA  Yes
HS Code  29222900
NFPA 704
0
2 0

2-Methoxy-4-nitroaniline price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 112631 2-Methoxy-4-nitroaniline 98% 97-52-9 100G ₹4535.68 2022-06-14 Buy
ALFA India ALF-B24220-36 2-Methoxy-4-nitroaniline, 99% 97-52-9 500g ₹16005 2022-05-26 Buy
ALFA India ALF-B24220-22 2-Methoxy-4-nitroaniline, 99% 97-52-9 100g ₹4199 2022-05-26 Buy
ALFA India ALF-B24220-14 2-Methoxy-4-nitroaniline, 99% 97-52-9 25g ₹1868 2022-05-26 Buy
TCI Chemicals (India) M0118 2-Methoxy-4-nitroaniline min. 99.0 % 97-52-9 25G ₹1500 2022-05-26 Buy
Product number Packaging Price Buy
112631 100G ₹4535.68 Buy
ALF-B24220-36 500g ₹16005 Buy
ALF-B24220-22 100g ₹4199 Buy
ALF-B24220-14 25g ₹1868 Buy
M0118 25G ₹1500 Buy

2-Methoxy-4-nitroaniline Chemical Properties,Uses,Production

Chemical Properties

2-Methoxy-4-nitroaniline is a yellow to orange crystalline powder. 2-Methoxy-4-nitroaniline (MONA) is a potential nonlinear optical (NLO) material, the N12–O19 bond length of MONA molecule is essentially controlled by the p-character of these hybrid orbitals and also by the nature of the N12–O19 bond. The molecular geometry of the compound is almost planar with the substituents[1].

Uses

2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives.

Uses

2-Methoxy-4-nitroaniline is an important intermediate for preparing organic pigments and color bases of ice dyeing dyestuff. As a benzene dye intermediate, It is generally employed to prepare not only fast pigments but also as a printing and dyeing developer for cotton fabrics. In particular, 2-methoxy-4-nitroaniline is also important in production of some antineoplastic drugs[2-3].

General Description

2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size.

Solubility in organics

The change trend of the solubility magnitude in different monosolvents from high to low was as follows: N-methylpyrrolidone (NMP) > dimethyl sulfoxide (DMSO) > 1,4-dioxane > ethyl acetate > acetonitrile > ethanol > methanol > n-propanol > isopropanol >  ethylene glycol (EG) > n-butanol > water[2].

References

[1] Bao Y, et al. 2-Methoxy-4-nitroaniline Solubility in Several Monosolvents: Measurement, Correlation, and Solvent Effect Analysis. Journal of Chemical & Engineering Data, 2020; 65: 757–765.
[2] Degawa M, et al.2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Letters, 1995; 96: 95-98.
[3] Ravikumar C, et al. Electronic absorption and vibrational spectra and nonlinear optical properties of 4-methoxy-2-nitroaniline. Physical Chemistry Chemical Physics, 2010; 12: 9452-9460.

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