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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Nimesulide

Nimesulide

Nimesulide Structure
  • ₹2200 - ₹56007
  • Product name: Nimesulide
  • CAS: 51803-78-2
  • MF: C13H12N2O5S
  • MW: 308.31
  • EINECS:257-431-4
  • MDL Number:MFCD00079470
  • Synonyms:nimed ;4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE;CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD);CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHOXY]ETHOXY]ACETIC ACID MM(CRM STANDARD);CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD);4-Nitro-2-phenoxymethanesulfonamide;Nide;Nidol
10 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 1gm
  • 1G
  • 5gm
  • 5G
  • 25gm
  • 25G
  • 100gm
  • ManufacturerTCI Chemicals (India)
  • Product numberN0984
  • Product descriptionNimesulide
  • Packaging1G
  • Price₹2200
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberN0984
  • Product descriptionNimesulide
  • Packaging5G
  • Price₹4500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN1016
  • Product descriptionNimesulide
  • Packaging1G
  • Price₹3085.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1336
  • Product descriptionNimesulide Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8919.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN1016
  • Product descriptionNimesulide
  • Packaging5G
  • Price₹9959
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN1016
  • Product descriptionNimesulide
  • Packaging25G
  • Price₹32648.2
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number N 1630
  • Product descriptionNimesulide, GR
  • Packaging1gm
  • Price₹2709
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number N 1630
  • Product descriptionNimesulide, GR
  • Packaging5gm
  • Price₹9045
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number N 1630
  • Product descriptionNimesulide, GR
  • Packaging25gm
  • Price₹29079
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number N 1630
  • Product descriptionNimesulide, GR
  • Packaging100gm
  • Price₹56007
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) N0984 Nimesulide 1G ₹2200 2022-05-26 Buy
TCI Chemicals (India) N0984 Nimesulide 5G ₹4500 2022-05-26 Buy
Sigma-Aldrich(India) N1016 Nimesulide 1G ₹3085.13 2022-06-14 Buy
Sigma-Aldrich(India) PHR1336 Nimesulide Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8919.8 2022-06-14 Buy
Sigma-Aldrich(India) N1016 Nimesulide 5G ₹9959 2022-06-14 Buy
Sigma-Aldrich(India) N1016 Nimesulide 25G ₹32648.2 2022-06-14 Buy
ottokemi N 1630 Nimesulide, GR 1gm ₹2709 2022-05-26 Buy
ottokemi N 1630 Nimesulide, GR 5gm ₹9045 2022-05-26 Buy
ottokemi N 1630 Nimesulide, GR 25gm ₹29079 2022-05-26 Buy
ottokemi N 1630 Nimesulide, GR 100gm ₹56007 2022-05-26 Buy

Properties

Melting point :140-146°C
Boiling point :442.0±55.0 °C(Predicted)
Density :1.451±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form :Solid
pka :pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
color :Light orange to Yellow to Green
Water Solubility :Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax :391nm(H2O)(lit.)
Merck :14,6548
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference :51803-78-2(CAS DataBase Reference)
EPA Substance Registry System :Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

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