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Cinacalcet hydrochloride

Cinacalcet hydrochloride Structure
CAS No.
364782-34-3
Chemical Name:
Cinacalcet hydrochloride
Synonyms
Cinacalcet HCl;N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride;(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propan-1-aMine hydrochloride;CS-502;AMG-073 HCl;calcimimetics;MIMPARA; SENSIPAR;Cinacalcet HCl D3;Cinacalcet R-isomer;Cinacalcet HCl,AMG073
CBNumber:
CB71176208
Molecular Formula:
C22H23ClF3N
Molecular Weight:
393.88
MOL File:
364782-34-3.mol
MSDS File:
SDS
Modify Date:
2024/7/15 17:50:29
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Cinacalcet hydrochloride Properties

Melting point 175-177°C
storage temp. Inert atmosphere,2-8°C
solubility insoluble in H2O; ≥17.85 mg/mL in DMSO; ≥56 mg/mL in EtOH
form solid
color White to off-white
InChI InChI=1/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/s3
InChIKey QANQWUQOEJZMLL-LSQUZMQTNA-N
SMILES C12C=CC=CC1=CC=CC=2[C@@H](C)NCCCC1=CC=CC(C(F)(F)F)=C1.Cl |&1:10,r|
CAS DataBase Reference 364782-34-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H314-H317-H373-H413
Precautionary statements  P260-P273-P280-P303+P361+P353-P305+P351+P338-P314
Safety Statements  24/25
HS Code  29214990
NFPA 704
0
3 0

Cinacalcet hydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2012 Cinacalcet hydrochloride ≥98% (HPLC) 364782-34-3 10MG ₹7978.03 2022-06-14 Buy
Sigma-Aldrich(India) SML2012 Cinacalcet hydrochloride ≥98% (HPLC) 364782-34-3 50MG ₹32280.15 2022-06-14 Buy
Product number Packaging Price Buy
SML2012 10MG ₹7978.03 Buy
SML2012 50MG ₹32280.15 Buy

Cinacalcet hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White to Tan Solid

Uses

Cinacalcet hydrochloride can be used in clinical trial in secondary hyperparathyroidism.

Uses

Cinacalcet hydrochloride is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

Definition

ChEBI: A hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride.

Biological Activity

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

Mechanism of action

Cinacalcet hydrochloride directly regulates a major regulator of parathyroid hormone (PTH) secretion, the calcium-sensitive receptor (CaR) on parathyroid master cells. Cinacalcet hydrochloride reduces circulating levels of PTH by increasing the sensitivity of the CaR to extracellular calcium.

Side effects

Cinacalcet hydrochloride was generally well tolerated in clinical trials. The severity of most treatment-emergent adverse events was mild to moderate. Common side effects of Cinacalcet hydrochloride include: nausea, vomiting, or unusual tiredness. Severe may also include low calcium levels in the blood, numbness/tingling of the skin; severe muscle cramps, seizures, and abnormal heartbeat.

Cinacalcet hydrochloride Preparation Products And Raw materials

Raw materials

1-Naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]-2-propen-1-ylidene]-, (αR)- Methanesulfonic acid 3-(3-trifluoroMethylphenyl)propyl ester Cinacalcet Impurity C (R)-(+)-1-(1-Naphthyl)ethylamine hydrochloride N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanaMide
1-BroMo-3-[3-(trifluoroMethyl)phenyl]propane CINACALCET (R)-(+)-1-(1-Naphthyl)ethylamine
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Preparation Products

Cinacalcet hydrochloride Suppliers

Global( 481)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Rampex Labs Private Limited +91 9168074433 Telangana, India 71 58 Inquiry
CLEANCHEM LABORATORIES LLP +91-9951015911 +91-9951015911 Mumbai, India 281 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Vivimed Labs Ltd +914066086608 Telangana, India 61 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Macleods Pharmaceuticals Limited +91-2266762800 +91-2266762800 Maharashtra, India 116 58 Inquiry
Unichem Laboratories Ltd +91-2266888333 +91-2266888333 Maharashtra, India 62 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Aruvi Labs +91-8056181939 +91-8056181939 Tamil Nadu, India 149 58 Inquiry
Megafine Pharma +91 9867686666, +91 9665458868 Maharashtra, India 29 58 Inquiry
Supplier Advantage
Rampex Labs Private Limited 58
CLEANCHEM LABORATORIES LLP 58
Dr. Reddy's Laboratories Ltd 58
Vivimed Labs Ltd 58
Hetero Drugs Limited 58
Macleods Pharmaceuticals Limited 58
Unichem Laboratories Ltd 58
HRV Global Life Sciences 58
Aruvi Labs 58
Megafine Pharma 58

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Cinacalcet hydrochloride Spectrum

Cinacalcet hydrochloride(364782-34-3)1HNMR

364782-34-3(Cinacalcet hydrochloride)Related Search:

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Ethyl acetate Ethylparaben PHENYL VALERATE D-Glucosamine hydrochloride Parathyroid
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(aR)-a-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride (R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1- -(1-napthyl)ethylamine Hydrochloride Cinacalcet Hydrochloride N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride -Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (.alpha.R)- (aR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride N-[(1R)-1-naphthalen-1-yleth [(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoroMethyl)phenyl]propyl})aMine hydrochloride AMG-073 HCl (Cinacalcet hydrochloride) (αR)-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl)propyl]-1-napthaleneMethanaMine Hydrochloride AMG 073 (Hydrochloride) AMG-073 (Cinacalcet hydrochloride) rac Cinacalcet-d3 (Methyl-d3) Hydrochloride Cinacalcet (R-EnantioMer) HCl 1-NaphthaleneMethanaMine,a-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-,hydrochloride (1:1), (aR)- AMG-073 HCl Cinacalcet hydrochloride N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride Cinacalcet(AMG-073) Hydrochloride Cinacalcet hydrochloride, >=99% 1-Naphthalenemethanamine, alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (alphaR)- Cinacalcet hydrochlodide AMG-073 HCl (Cinacalcet HCl) Cinacalcet HCl,AMG073 CINACALCET HCL;MIMPARA; SENSIPAR calcimimetics (R)-Cinacalcet Hydrochloride Cinacalcet (AMG-073) HCl MIMPARA; SENSIPAR (R)-N-(1-(naphthalen-1-yl)ethyl)- CS-502 Cinacalcet hydrochloride CAS NO.364782-34-3 Hot sale Cinacalcet hydrochloride 99%min Top quality Cinacalcet hydrochloride with best price Cinacalcet hydrochloride CAS:364782-34-3 with fast delivery Cinacalcet HCl D3 Cinacalcet Hydrochloride (250 mg) 1-Naphthalenemethanamine,a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride, (aR)- Cinacalcet hydrochloride USP/EP/BP Cinacalcet R-isomer Cinacalcet Hydrochkoride (cGMP) (R)-CINACALCET-D3 HYDROCHLORIDE nacalcet hydrochloride Cinacalcet HydrochlorideQ: What is Cinacalcet Hydrochloride Q: What is the CAS Number of Cinacalcet Hydrochloride Q: What is the storage condition of Cinacalcet Hydrochloride Q: What are the applications of Cinacalcet Hydrochloride TIANFU CHEM--Cinacalcet hydrochloride Cinacalcet Hydrochkoride Cinacalcet Hydrochloride (1133977) Cinacalcet HCl (R-Enantiomer) (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propan-1-aMine hydrochloride Cinacalcet HCl N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride Sinacase hydrochloride Cinoxacin hydrochloride 364782-34-3 C22H23ClF3N C22H22F3NHCl C22H22F3NClH Inhibitors Mimpara, Sensipar