CINACALCET
- CAS No.
- 226256-56-0
- Chemical Name:
- CINACALCET
- Synonyms
- Sensipar;[(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoroMethyl)phenyl]propyl})aMine;AMG 073;Mimpara;Regpara;KRN 1493;Hsdb 7318;Cinacalce;Sinacasse;Sinakasse
- CBNumber:
- CB5506688
- Molecular Formula:
- C22H22F3N
- Molecular Weight:
- 357.42
- MOL File:
- 226256-56-0.mol
- Modify Date:
- 2024/4/2 15:24:10
| Boiling point | 440.9±45.0 °C(Predicted) |
|---|---|
| Density | 1.154±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 9.19±0.29(Predicted) |
| color | Yellow |
| InChI | InChI=1/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/s3 |
| InChIKey | VDHAWDNDOKGFTD-QEIABERDNA-N |
| SMILES | [C@H](C1=CC=CC2C=CC=CC1=2)(C)NCCCC1C=CC=C(C(F)(F)F)C=1 |&1:0,r| |
| CAS DataBase Reference | 226256-56-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H360 |
| Precautionary statements | P201-P202-P264-P270-P280-P301+P312-P302+P352-P305+P351+P338-P308+P313-P321-P330-P332+P313-P337+P313-P362+P364-P405-P501 |
CINACALCET Chemical Properties,Uses,Production
Description
Cinacalcet is the first type II calcimimet ic agent approved that improves CaSR sensi Tivity to calcium . When calcium is bound to the CaSR, phospholipase C is act ivated, and the secretion of PTH is inhibited. In the presence of cinacalcet , not only is a drop in PTH levels observed but also a decrease in serum calcium and phosphorous levels.
Chemical Properties
Yellow Oil
Uses
Cinacalcet is the first calcimimetic drug approved by the United States Food and Drug Administration for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
Definition
ChEBI: Cinacalcet is a secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. It has a role as a calcimimetic and a P450 inhibitor. It is a member of naphthalenes, a secondary amino compound and a member of (trifluoromethyl)benzenes.
Clinical Use
Cinacalcet hydrochloride is a second-generat ion calcimimetic approved for the treatment of secondary hyperparathyroidism in patients wi th chronic kidney disease on dialysis and for the treatment of hypercalcemia in patients with parathyroid cancer . It can be used alone, with vitamin D, and/or with a phosphate binder .
Side effects
Common side effects of Cinacalcet are nausea, vomiting, dizziness, diarrhoea and loss of appetite.Cinacalcet can cause hypocalcaemia. Patients taking this medication need to be followed closely for common symptoms associated with hypocalcaemia, including tingling, muscle twitching, cramps, mood changes or irritability. On the ECG, there may be a prolonged QT interval. Patients with a history of congenital long QT syndrome, a family history of long QT syndrome, and other conditions predisposing them to prolonged QT intervals may be at increased risk. PTH oversupport can lead to ankylosing bone disease.
CINACALCET Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Mumbai, India | 66 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| Zydus Lifesciences Ltd. | +91-0265-2315243 +91-6358895661 | Gujarat, India | 89 | 58 | Inquiry |
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| J S LABS | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Lupin Ltd | 58 |
| Aarti Industries Limited (AIL) | 58 |
| Zydus Lifesciences Ltd. | 58 |
| Laurus Labs Ltd | 58 |
| Vijaya Pharma And Life Science | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Related articles
- Cinacalcet: Application, Mechanism of action and Side effects
- Cinacalcet is an orthosteric modulator of the calcium-sensitive receptor (CaSR) and acts as a calcimimetic.
- Apr 2，2024
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