1-(1-NAPHTHYL)-2-THIOUREA
- CAS No.
- 86-88-4
- Chemical Name:
- 1-(1-NAPHTHYL)-2-THIOUREA
- Synonyms
- ANTU;AUTU;Bantu;Dirax;Alrato;u-5227;Kripid;Krysid;Rat-Tu;U 5227
- CBNumber:
- CB5308200
- Molecular Formula:
- C11H10N2S
- Molecular Weight:
- 202.28
- MOL File:
- 86-88-4.mol
- Modify Date:
- 2024/3/14 15:18:26
| Melting point | 193 °C |
|---|---|
| Boiling point | 377.6±25.0 °C(Predicted) |
| Density | 1.333 |
| refractive index | 1.5500 (estimate) |
| storage temp. | Poison room |
| solubility | 4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983) |
| pka | 13.12±0.70(Predicted) |
| form | Crystals or Crystalline Powder |
| color | Grayish to beige-brown |
| Odor | bitter taste |
| Water Solubility | 600 mg/L at 20 °C (quoted, Windholz et al., 1983) |
| Merck | 14,722 |
| BRN | 778118 |
| Exposure limits | NIOSH REL: TWA 0.3 mg/m3, IDLH 100 mg/m3; OSHA PEL: TWA 0.3 mg/m3 |
| CAS DataBase Reference | 86-88-4(CAS DataBase Reference) |
| IARC | 3 (Vol. 30, Sup 7) 1987 |
| EPA Substance Registry System | .alpha.-Naphthylthiourea (86-88-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H351 | |||||||||
| Precautionary statements | P201-P202-P264-P270-P280-P301+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-40 | |||||||||
| Safety Statements | 28-36/37-45-25-23 | |||||||||
| RIDADR | 1651 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.3 mg/m3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | YT9275000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29309090 | |||||||||
| Toxicity | Acute oral LD50 for Norwegian rats 6–8 mg/kg (Hartley and Kidd, 1987). | |||||||||
| IDLA | 100 mg/m3 | |||||||||
| NFPA 704 |
|
1-(1-NAPHTHYL)-2-THIOUREA price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 45328 | ANTU PESTANAL?, analytical standard | 86-88-4 | 250MG | ₹5098.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0071 | 1-(1-Naphthyl)-2-thiourea | 86-88-4 | 5G | ₹3400 | 2022-05-26 | Buy |
| ALFA India | ALF-A19024-30 | N-(1-Naphthyl)thiourea, 97% | 86-88-4 | 250g | ₹48682 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0071 | 1-(1-Naphthyl)-2-thiourea | 86-88-4 | 25G | ₹11300 | 2022-05-26 | Buy |
| ALFA India | ALF-A19024-18 | N-(1-Naphthyl)thiourea, 97% | 86-88-4 | 50g | ₹12219 | 2022-05-26 | Buy |
1-(1-NAPHTHYL)-2-THIOUREA Chemical Properties,Uses,Production
Description
a-Naphthylthiourea (ANTU; also called DIRAX) is toxic by inhalation, ingestion, or skin contact. Due to its very narrow spectrum of activity, production was discontinued a long time ago. Exposure to ANTU causes pulmonary edema; therefore, it is often used as an experimental pneumotoxin. ANTU is a graycolored, prism-shaped, odorless powder with a bitter taste. It has a molecular weight of 202.28 and melting point of 200 ℃ and does not ignite readily. However, on interaction with potential oxidizing agents, it may cause fire and explosions, which can lead to hazardous decomposition products such as sulfur dioxide, nitrogen dioxide, and carbon monoxide. The structure of ANTU contains the naphthalene chromophore, which absorbs UV light at ～311 nm. This suggests that ANTU can undergo photolysis.
Chemical Properties
greyish to beige-brown crystals or cryst. powder
Physical properties
Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.
Uses
Rodenticide. Specific control for the adult Norway rat; less toxic to other rat species.
General Description
White crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .
Hazard
Toxic by ingestion
Health Hazard
Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.
Fire Hazard
Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx.
Potential Exposure
ANTU or its formulations are used as a rodenticide.
Carcinogenicity
ANTU was not carcinogenic in rodent feeding studies.4 Cases of bladder tumors among rat catchers exposed to ANTU have been attributed to b-naphthylamine, a manufacturing impurity of ANTU. In bacterial assays ANTU induced mutations.
Environmental Fate
Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was
determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition
(Lewis, 1990)
storage
α-Naphthalene thiourea should be kept stored in a tightly closed container in a locked poison room, in a cool, dry, well-ventilated area away from incompatible substances.
Shipping
UN1651 Naphthylthiourea, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, silver nitrate.
Waste Disposal
Incinerate in a furnace equipped with an alkaline scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Precautions
Workers should use/handle α-naphthalene thiourea with adequate ventilation. During use, dust generation and accumulation should be minimum, and avoid contact with the eyes, skin, and clothing.
1-(1-NAPHTHYL)-2-THIOUREA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 8673 | 58 | Inquiry |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | China | 23053 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
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