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simfibrate

simfibrate Structure
CAS No.
14929-11-4
Chemical Name:
simfibrate
Synonyms
CLY-503;Sinfibrate;simfibrate;Cholesolvin;simfibrate USP/EP/BP;1,3-Propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate];Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate);Bis[2-(4-chlorophenoxy)-2-methylpropanoic acid] 1,3-propanediyl;Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 1,1'-(1,3-propanediyl) ester;3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methylpropanoate
CBNumber:
CB4875031
Molecular Formula:
C23H26Cl2O6
Molecular Weight:
469.35
MOL File:
14929-11-4.mol
Modify Date:
2023/5/4 17:34:33
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simfibrate Properties

Melting point 51-53°
Boiling point bp0.03 197-200°; bp0.15 220-230°
Density 1.2623 (estimate)

SAFETY

Risk and Safety Statements

Toxicity LD50 in mice, rats (g/kg): 3.3-3.5; 7.3-8.0 orally (Nakanishi, J. Pharm. Soc. Japan)

simfibrate Chemical Properties,Uses,Production

Originator

Cholesorbin,Takeda,Japan,1971

Manufacturing Process

A mixture of 22 grams of α-(p-chlorophenoxy)isobutyric acid, 3.8 grams of 1,3-propanediol, 0.5 gram of p-toluenesulfonic acid and 150 ml of xylene was refluxed. When the theoretically calculated amount of water had been removed, the xylene solution was washed with dilute aqueous sodium bicarbonate and then the xylene was distilled off. The residue was distilled under reduced pressure to give 11 grams (47% yield) of 1,3-propanediol bis[α-(p-chlorophenoxy)isobutyrate] boiling at 197° to 200°C/0.03 mm Hg.

Therapeutic Function

Antihyperlipidemic

simfibrate Preparation Products And Raw materials

Raw materials

1,3-Propanediol, 2-(2,2-diethoxyethyl)-,monoacetate,(R)-

Preparation Products

simfibrate Suppliers

Global( 17)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aikon International Limited 025-58851090 13611564524 China 15952 58 Inquiry
Shaanxi Dideu Newmaterial Co., Ltd. 029-63373950 15353716720 China 10011 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 23963 58 Inquiry
Waterstone Technology, LLC 317 644 0862 United States 6801 30 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6343 56 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Shaanxi Dideu Medichem Co. Ltd 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Aikon International Limited 58
Shaanxi Dideu Newmaterial Co., Ltd. 58
TargetMol Chemicals Inc. 58
Waterstone Technology, LLC 30
Lanospharma Laboratories Co.,Ltd 56

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simfibrate 1,3-Propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate] Bis[2-(4-chlorophenoxy)-2-methylpropanoic acid] 1,3-propanediyl Cholesolvin CLY-503 Sinfibrate simfibrate USP/EP/BP Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 1,1'-(1,3-propanediyl) ester Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate) 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methylpropanoate 14929-11-4 C23H26Cl2O6