1-(1-ナフチル)-2-チオ尿素 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
用途
農薬(殺ソ剤)
説明
a-Naphthylthiourea (ANTU; also called DIRAX) is toxic by
inhalation, ingestion, or skin contact. Due to its very narrow
spectrum of activity, production was discontinued a long time
ago. Exposure to ANTU causes pulmonary edema; therefore, it
is often used as an experimental pneumotoxin. ANTU is a graycolored,
prism-shaped, odorless powder with a bitter taste. It
has a molecular weight of 202.28 and melting point of 200 ℃
and does not ignite readily. However, on interaction with
potential oxidizing agents, it may cause fire and explosions,
which can lead to hazardous decomposition products such as
sulfur dioxide, nitrogen dioxide, and carbon monoxide. The
structure of ANTU contains the naphthalene chromophore,
which absorbs UV light at ～311 nm. This suggests that ANTU
can undergo photolysis.
化学的特性
greyish to beige-brown crystals or cryst. powder
物理的性質
Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.
使用
Rodenticide. Specific control for the adult Norway rat; less toxic to other rat species.
一般的な説明
White crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.
空気と水の反応
Slightly soluble in water.
反応プロフィール
1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .
危険性
Toxic by ingestion
健康ハザード
Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.
火災危険
Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.
安全性プロファイル
Poison by ingestion and
intraperitoneal routes. Moderately toxic to
humans by an unspecified route.
Questionable carcinogen with experimental
tumorigenic data. Mutagenic data. A
rodenticide used extensively. Death is
caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis
and a decrease in the white blood cells.
When heated to decomposition it emits
toxic fumes of NOx and SOx.
職業ばく露
ANTU or its formulations are used as
a rodenticide.
発がん性
ANTU was not carcinogenic in rodent
feeding studies.4 Cases of bladder tumors
among rat catchers exposed to ANTU have
been attributed to b-naphthylamine, a manufacturing
impurity of ANTU. In bacterial
assays ANTU induced mutations.
環境運命予測
Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was
determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition
(Lewis, 1990)
貯蔵
α-Naphthalene thiourea should be kept stored in a tightly closed container in a locked
poison room, in a cool, dry, well-ventilated area away from incompatible substances.
輸送方法
UN1651 Naphthylthiourea, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials.
純化方法
Crystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]
不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, silver nitrate.
廃棄物の処理
Incinerate in a furnace
equipped with an alkaline scrubber. Consult with environmental
regulatory agencies for guidance on
acceptable disposal practices. Generators of waste containing
this contaminant (≥100 kg/mo) must conform with
EPA regulations governing storage, transportation, treatment,
and waste disposal.
予防処置
Workers should use/handle α-naphthalene thiourea with adequate ventilation. During
use, dust generation and accumulation should be minimum, and avoid contact with the
eyes, skin, and clothing.
1-(1-ナフチル)-2-チオ尿素 上流と下流の製品情報
原材料
準備製品