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2-PHENYLPROPIONIC ACID

2-PHENYLPROPIONIC ACID Structure
CAS No.
492-37-5
Chemical Name:
2-PHENYLPROPIONIC ACID
Synonyms
HYDRATROPIC ACID;Benzeneacetic acid, .alpha.-methyl-;2-Phenylproplonic Acid;(±)-α-methylphenylaceticacid;(±)-2-Phenylpropionic acid, (±)-Hydratropic acid;dl-PPA;2-Phenylpropionic;RARECHEM AL BO 0089;TIMTEC-BB SBB007855;DL-HYDRATROPIC ACID
CBNumber:
CB9293539
Molecular Formula:
C9H10O2
Molecular Weight:
150.18
MOL File:
492-37-5.mol
MSDS File:
SDS
Modify Date:
2024/7/16 18:25:32

2-PHENYLPROPIONIC ACID Properties

Melting point 5 °C
Boiling point 260-262 °C (lit.)
Density 1.1 g/mL at 25 °C (lit.)
refractive index n20/D 1.522(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility 9.9g/l
form Liquid
pka 4.34±0.10(Predicted)
color Clear pale yellow to yellow
PH 3 (5g/l, H2O, 20℃)
Water Solubility 10 g/L (20 ºC)
BRN 1863558
LogP 1.699 (est)
CAS DataBase Reference 492-37-5(CAS DataBase Reference)
NIST Chemistry Reference Benzeneacetic acid, «alpha»-methyl-(492-37-5)
EPA Substance Registry System Benzeneacetic acid, .alpha.-methyl- (492-37-5)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P305+P351+P338+P310
Hazard Codes  Xi,C
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
TSCA  Yes
HS Code  29163900
NFPA 704
1
1 0

2-PHENYLPROPIONIC ACID price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P31701 2-Phenylpropionic acid 97% 492-37-5 5G ₹1937.68 2022-06-14 Buy
Sigma-Aldrich(India) P31701 2-Phenylpropionic acid 97% 492-37-5 10G ₹3561.43 2022-06-14 Buy
TCI Chemicals (India) P0699 DL-2-Phenylpropionic Acid min. 98.0 % 492-37-5 5G ₹2100 2022-05-26 Buy
ALFA India ALF-L00709-22 (+/-)-2-Phenylpropionic acid, 98% 492-37-5 100g ₹32071 2022-05-26 Buy
TCI Chemicals (India) P0699 DL-2-Phenylpropionic Acid min. 98.0 % 492-37-5 25G ₹5600 2022-05-26 Buy
Product number Packaging Price Buy
P31701 5G ₹1937.68 Buy
P31701 10G ₹3561.43 Buy
P0699 5G ₹2100 Buy
ALF-L00709-22 100g ₹32071 Buy
P0699 25G ₹5600 Buy

2-PHENYLPROPIONIC ACID Chemical Properties,Uses,Production

Chemical Properties

clear pale yellow to yellow liquid

Uses

2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.

Definition

ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon.

Synthesis

2-Phenylpropionic acid is prepared:
1) from Benzyl cyanide by Metbylation with Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the acid is produced by acid hydrolysis.
2) from Acetophenone cyanhydrin with Hydriodic acid. 

Purification Methods

Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.]

2-PHENYLPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(n)-2-phenylpropionic acid (n)-à-methylphenylacetic acid 2-HENYLPROPIONIC ACID 2-PHENYLPROPINICACID dl-PPA α-methyl-α-toluic acid 2-PHENYLPROPIONIC ACID 98% DL-α-phenylpropionic acid a-Methylbenzeneacetic acid rac-(2R*)-2-Phenylpropionic acid rac-(R*)-2-Phenylpropanoic acid DL-2-Phenylpropionic acid,98% RARECHEM AL BO 0089 (+/-)-2-PHENYLPROPIONIC ACID 2-PHENYLPROPIONIC ACID α-methylbenzeneaceticacid α-methylphenylaceticacid TIMTEC-BB SBB007855 a-Methylphenylacetic acid ALPHA-METHYLPHENYLACETIC ACID HYDRATROPIC ACID 95% (GC) (+/-)-2-Phenylpropionicacid,98% 2-Phenylpropionic (+/-)-HYDRATROPIC ACID DL-HYDRATROPIC ACID DL-2-PHENYLPROPIONIC ACID DL-2-Phenylpropionic acid, 98% 10GR 2-Phenylpropionic Acid, 97+% (RS)-2-phenylpropionicacid alpha-Methylbenzeneacetic acid alpha-methyl-benzeneaceticaci alpha-Phenylpropionic acid benzeneaceticacid,α-methyl- dl-alpha-Phenylpropionic acid Propanoic acid, 2-phenyl (2S)-2-phenylpropanoate DL-2-PhenylpropionicAcid> Benzeneacetic acid, .alpha.-methyl- (±)-2-Phenylpropionic acid, (±)-Hydratropic acid HYDRATROPIC ACID (±)-α-methylphenylaceticacid 2-Phenylproplonic Acid 2-pronyl propionic acid Benzeneacetic acid, α-methyl- 492-37-5 CH3CHC6H5COOH C6H5CHCH3COOH Carbonyl Compounds C9 Carboxylic Acids Building Blocks Organic Building Blocks CARBOXYLIC ACID Carboxylic Acids Aliphatics Carboxylic Acids Organic acids Pharmaceutical Intermediates