Nandrolone phenylpropionate
- CAS No.
- 62-90-8
- Chemical Name:
- Nandrolone phenylpropionate
- Synonyms
- NTPP;19Ntpp;Activin;Durabol;Nerobil;SK 22271;NSC-23162;Durabolin;Fenobolin;Nandrolin
- CBNumber:
- CB3680120
- Molecular Formula:
- C27H34O3
- Molecular Weight:
- 406.57
- MOL File:
- 62-90-8.mol
- Modify Date:
- 2024/5/30 19:23:35
| Melting point | 85-87°C |
|---|---|
| alpha | D +58° (chloroform) |
| Boiling point | 487.61°C (rough estimate) |
| Density | 1.0140 (rough estimate) |
| refractive index | 1.5460 (estimate) |
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | DMSO : 100 mg/mL (245.97 mM; Need ultrasonic) |
| form | Solid |
| color | White to Off-White |
| InChIKey | UBWXUGDQUBIEIZ-QNTYDACNSA-N |
| SMILES | C[C@]12CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCC1C=CC=CC=1 |&1:1,4,6,16,18,22,r| |
| CAS DataBase Reference | 62-90-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Androstene-17-beta-ol-3-one, 19-nor-delta-, phenylpropionate(62-90-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H351-H360FD |
| Precautionary statements | P201-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-40 |
| Safety Statements | 23-36 |
| RTECS | KG7995000 |
| Toxicity | LD50 intraperitoneal in mouse: > 1gm/kg |
Nandrolone phenylpropionate Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Anabolic steroid; androgen.
World Health Organization (WHO)
Nandrolone phenylpropionate, an anabolic steroid, was introduced in 1959. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of nandrolone phenylpropionate remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.
Synthesis
Nandrolone phenylpropionate is prepared by reacting anhydrous MeCN with a mixture of 3-phenylpropanoic acid, aryneprecursor, nandrolone CsF, K2CO3, and 18-crown-6 in 70 ?? in an oil bath.
Add anhydrous MeCN (0.5 mL) to a mixture of 3-phenylpropanoic acid (30.0 mg, 0.2 mmol, 1.0 equiv), aryneprecursor (119.2 mg, 0.4 mmol, 2.0 equiv), nandrolone (82.3 mg, 0.3 mmol, 1.5 equiv), CsF (182.3 mg, 1.2 mmol, 6.0 equiv), K2CO3 (82.9 mg, 0.6 mmol, 3.0 equiv), and 18-crown-6 (158.6 mg, 0.6 mmol, 3.0 equiv). Warm the mixture to 70 ?? in an oil bath and stir at this temperature for8 hours. Remove all the volatiles directly on rotary evaporator. Purify by flash column chromatography with pet ether:EtOAc = 20:1. 1H NMR (400 MHz, CDCl3) |? 7.31-7.26(m,2H), 7.23-7.17(m,3H), 5.83 (s, lH), 4.65-4.58(m, lH), 2.95(t, J= 8.0 Hz,2H), 2.64(t, J= 8.0 Hz,2H), 2.51-2.36(m, 2H), 2.31-2.04(m, 5H), 1.86-1.79(m, 2H), 1.72-1.61 (m, 2H), 1.57-1.00(m, 8H),0.90-0.81(m, 1H), 0.79 (s, 3H)ppm.
Fig The synthetic method 1 of Nandrolone phenylpropionate
Nandrolone phenylpropionate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Asg Biochem Pvt. Ltd | +91-9650436669 +91-9650436669 | New Delhi, India | 25 | 58 | Inquiry |
| Shakti Life Science | +91-9930420063 +91-9930420063 | Maharashtra, India | 28 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Brichem Life Sciences Pvt Ltd | +91-9879109660 +91-9427536568 | Gujarat, India | 11 | 58 | Inquiry |
| Symbiotec Pharma Lab Pvt Ltd | +91-7316676406 +91-7316676405 | Madhya Pradesh, India | 71 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Om Sales Chemie | 08047625958 | Vadodara, India | 22 | 58 | Inquiry |
| Cekem Health Care | 07942549627 | Punjab, India | 2 | 58 | Inquiry |
| Shanghai Longyu Biotechnology Co., Ltd. | +8613917842738 | China | 2534 | 58 | Inquiry |
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