Danazol
- CAS No.
- 17230-88-5
- Chemical Name:
- Danazol
- Synonyms
- danazole;danocrine;Danazol Usp;17α-Pregna-2,4-dien-20-yne-[2,3-d]isoxazole-17b-ol;4-ANDROSTEN-[2,3-D]ISOXAZOLE-17-ALPHA-ETHYNYL-17-BETA-OL;1H-Cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol, 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl- (7CI);Dano;danol;Bonzol;DANZOL
- CBNumber:
- CB9463336
- Molecular Formula:
- C22H27NO2
- Molecular Weight:
- 337.46
- MOL File:
- 17230-88-5.mol
- Modify Date:
- 2023/6/8 9:02:17
| Melting point | 224.4-226.80C |
|---|---|
| alpha | D25 +7.5° (ethanol); D25 +21.9° (chloroform) |
| Boiling point | 473.76°C (rough estimate) |
| Density | 1.0909 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pka | 13.10±0.60(Predicted) |
| form | Solid |
| color | White to Pale Yellow |
| Water Solubility | Partly soluble in water. Soluble in chloroform (25 mg/ml), acetone, acetonitrile, and ethanol. 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole and 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol are the synonym of this compound. |
| EPA Substance Registry System | Danazol (17230-88-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312+H332-H361 | |||||||||
| Precautionary statements | P201-P280-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-63-36/37/38 | |||||||||
| Safety Statements | 22-36-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU4157070 | |||||||||
| HS Code | 29372900 | |||||||||
| Toxicity | dog,LD50,oral,> 5gm/kg (5000mg/kg),Journal of International Medical Research. Vol. 5(Suppl, | |||||||||
| NFPA 704 |
|
Danazol price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D8399 | Danazol ≥98% | 17230-88-5 | 100MG | ₹9277.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D8399 | Danazol ≥98% | 17230-88-5 | 250MG | ₹20621.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D8399 | Danazol ≥98% | 17230-88-5 | 1G | ₹59862.25 | 2022-06-14 | Buy |
Danazol Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Danazol is an anterior pituitary supressant. Danazol is an anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin.
Indications
Danazol, a synthetic androgen, has been used to treat the pruritus of primary biliary cirrhosis, urticaria, and also idiopathic pruritus. It has been used for treatment of pruritus associated with polycythemia vera and systemic lupus erythematosus.
General Description
Danazol, 17α-pregna-2,4-dien-20-yno-[2,3-d]isoxazol-17-ol, is a weak androgen that, in spite ofthe 17α-ethinyl group, has little estrogenic or progestogenicactivity. Danazol has been called a synthetic steroidwith diverse biological effects. Danazol binds to sexhormone–binding globulin (SHBG) and decreases the hepaticsynthesis of this estradiol and testosterone carrier.Free testosterone thus increases. Danazol inhibits FSH andLH production by the hypothalamus and pituitary. It bindsto PRs, GRs, ARs, and ERs. Although the exact mechanismof action is unclear, danazol alters endometrial tissueso that it becomes inactive and atrophic, which allowsdanazol to be an effective treatment for endometriosis.Danazol is also used to treat hereditary angioedema and fibrocysticbreast disease.
Side effects
Danazol, a synthetic analogue of 17α-ethynyl testosterone, induces amenorrhea, anovulation and endometrial atrophy via suppression of the hypothalamicpituitary-ovary (HPO) axis. This causes an estrogen-deficient state, but it also causes an increase in androgen production. Danazol generally is not well tolerated because of its androgenic and anabolic side effects, including acne, decreased breast size, facial hair, weight gain, and oily skin. This type of therapy is not a viable option for women with liver disease or hyperlipidemia. Because danazol is teratogenic , it is recommended that effective contraception be utilized during treatment.
Danazol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
| Coral Drugs Pvt Ltd | +91-1244518100 +91-8199986118 | New Delhi, India | 24 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Prachem Laboratories | +91-7948993109 +91-7383072020 | Gujarat, India | 44 | 58 | Inquiry |
| Dy - Mach Pharma | +91-2265018321 +91-2226833227 | Maharashtra, India | 18 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Micron Pharmaceuticals | 91-22-24969511 | Maharashtra, India | 43 | 58 | Inquiry |
| Parth Overseas | 91-22-28802773 | Maharashtra, India | 50 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Micro Orgo Chem | 58 |
| Coral Drugs Pvt Ltd | 58 |
| Cipla Ltd | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Prachem Laboratories | 58 |
| Dy - Mach Pharma | 58 |
| Ralington Pharma | 58 |
| Micron Pharmaceuticals | 58 |
| Parth Overseas | 58 |
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