Isoxazole
- CAS No.
- 288-14-2
- Chemical Name:
- Isoxazole
- Synonyms
- ISOXAZOLE;Isooxazole;Isoxazolec;1,2-Oxazole;Isoxazole>Isoxazole,99%;Isoxazole 99%;ISOXAZOLE 98+%;Isoxazole, 98.5%;Different oxazole
- CBNumber:
- CB3485864
- Molecular Formula:
- C3H3NO
- Molecular Weight:
- 69.06
- MOL File:
- 288-14-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/4 9:01:33
| Melting point | -67.1°C |
|---|---|
| Boiling point | 93-95 °C(lit.) |
| Density | 1.078 g/mL at 25 °C(lit.) |
| vapor density | 2.4 (vs air) |
| refractive index |
n |
| Flash point | 48 °F |
| storage temp. | 2-8°C |
| solubility | 167g/l |
| pka | -2.0(at 25℃) |
| form | clear liquid |
| color | Colorless to Light yellow |
| BRN | 103773 |
| InChIKey | CTAPFRYPJLPFDF-UHFFFAOYSA-N |
| CAS DataBase Reference | 288-14-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Isoxazole(288-14-2) |
| EPA Substance Registry System | Isoxazole (288-14-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225 | |||||||||
| Precautionary statements | P210 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11 | |||||||||
| Safety Statements | 16-23/33-33-29-7/9 | |||||||||
| RIDADR | UN 1993 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Highly Flammable | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
Isoxazole price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 151637 | Isoxazole 99% | 288-14-2 | 5G | ₹2208.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 151637 | Isoxazole 99% | 288-14-2 | 25G | ₹9136.3 | 2022-06-14 | Buy |
| ALFA India | ALF-L01607-06 | Isoxazole, 99% | 288-14-2 | 5g | ₹1102 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0372 | Isoxazole min. 95.0 % | 288-14-2 | 5G | ₹4000 | 2022-05-26 | Buy |
Isoxazole Chemical Properties,Uses,Production
Description
Isoxazole, an important class of heterocycles, is a five membered heterocyclic compound that exhibits various pharmacological actions. It is present in some natural products such as ibotenic acid and is also used as a foundation for several drugs such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.
Chemical Properties
A colorless liquid resembling pyridine. It is soluble in water at room temperature up to six times its volume.
Uses
Natural insecticide.
Definition
ChEBI: Isoxazole is a monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. It is a mancude organic heteromonocyclic parent, a monocyclic heteroarene and a member of isoxazoles.
Preparation
Isoxazoles can be synthesized by various methods, such as the 1,3-dipolar cycloaddition reaction of nitrile oxides with alkynes, the reaction of hydroxylamine with 1,3-diketones or propiolic acid derivatives, etc.
www.organic-chemistry.org
General Description
Isoxazole(288-14-2) are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter.
Hazard
Narcotic and psychomimetic effects.
References
https://en.wikipedia.org/wiki/Isoxazole
https://pubchem.ncbi.nlm.nih.gov/compound/9254
Isoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
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