Risperidone
- CAS No.
- 106266-06-2
- Chemical Name:
- Risperidone
- Synonyms
- RISPERDAL;RISPERIDAL;Risperdal Consta;Risperidone(Risperdal);3-[2-4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one, R-64766, Belivon, Risperdal;Spiron;R-64766;BELIVON;CS-2004;Rispadal
- CBNumber:
- CB9131730
- Molecular Formula:
- C23H27FN4O2
- Molecular Weight:
- 410.48
- MOL File:
- 106266-06-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/13 17:47:58
| Melting point | 170°C |
|---|---|
| Boiling point | 572.4±60.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| pka | pKa 8.3 (Uncertain) |
| form | powder |
| color | white to off-white |
| Water Solubility | 44.74mg/L(25 ºC) |
| Merck | 14,8233 |
| BCS Class | 2 |
| CAS DataBase Reference | 106266-06-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 25-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 28-36-45-36/37-16 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UV1164800 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29333990 | |||||||||
| Toxicity | LD50 in male, female mice, rats, dogs (mg/kg): 29.7, 26.9, 34.3, 35.4, 14.1, 18.3 i.v.; 82.1, 63.1, 113, 56.6, 18.3, 18.3 orally (Janssen, 1988) | |||||||||
| NFPA 704 |
|
Risperidone price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R3030 | Risperidone ≥98% (HPLC), powder | 106266-06-2 | 10MG | ₹14527.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R3030 | Risperidone ≥98% (HPLC), powder | 106266-06-2 | 50MG | ₹69420.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R-006 | Risperidone solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 106266-06-2 | 1ML | ₹10041.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1631 | Risperidone Pharmaceutical Secondary Standard; Certified Reference Material | 106266-06-2 | 500MG | ₹19149.43 | 2022-06-14 | Buy |
| TCI Chemicals (India) | R0087 | Risperidone | 106266-06-2 | 50MG | ₹7600 | 2022-05-26 | Buy |
Risperidone Chemical Properties,Uses,Production
Description
Risperidone is a novel antipsychotic introduced for the treatment of acute and chronic schizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonist activity. While the anti-D2 activity may relate to the antipsychotic potency of neuroleptic agents, an antidepressive efficacy of substances with anti-5-HT2 activity has been suggested. Risperidone, therefore, has therapeutic action on both positive and negative symptoms of schizophrenia and produces significantly fewer side effects especially extrapyramidal symptoms compared with commonly used pure D2 antagonist antipsychotics. It also has potential for management of alcohol withdrawal and cocaine addiction.
Chemical Properties
Crystalline Solid
Uses
Risperidone has been used:
- to study its effects on bone formation and differentiation
- to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients
- to reverse induced schizophrenia-like behavior in mice
Definition
ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
General Description
Risperidone (Risperdal, a benzisoxazole)has the structural features of a hybrid molecule between abutyrophenone antipsychotic and a trazodone-like antidepressant.Its superior side effects profile (compared withhaloperidol) at dosage of 6 mg/d or less and the lower riskof tardive dyskinesia have contributed to its very widespreaduse. It benefited refractory psychotic patients, withparkinsonism controlled at one tenth the dose of antiparkinsoniandrugs used with haloperidol.Coexisting anxietyand depressive syndromes were also lessened. It is reportedto decrease the negative (e.g., withdrawal, apathy) as well asthe positive (e.g., delusions, hallucinations) symptoms ofschizophrenia. This is reportedly a consequence of the compound’scombination 5-HT2–D2 receptor antagonistic properties.Overall, the reasons for the decreased EPS and effectiveness against negative symptom are still under investigation.It is an important atypical antipsychotic.Risperidone is metabolized in the liver by CYP2D6 to anactive metabolite, 9-hydroxyrisperidone. Because thismetabolite and risperidone are nearly equipotent, the clinicalefficacy of the drug reflects both compounds.
Biological Activity
Atypical antipsychotic agent that displays 5-HT 2A receptor antagonism. Also displays high affinity at D 2 receptors (K i values are 0.4 and 3.13 nM for 5-HT 2A and D 2 receptors respectively).
Risperidone Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Dodhia Group | +91-9619867345 +91-9619867345 | Mumbai, India | 129 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| JPN Pharma Pvt Ltd | +919833233531 | Maharashtra, India | 33 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANWITA APIS | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| Jigs Chemical ltd | 58 |
| Gonane Pharma | 58 |
| Dodhia Group | 58 |
| Aurobindo Pharma Limited | 58 |
| Apotex Pharmachem India Pvt Ltd | 58 |
| Cipla Ltd | 58 |
| JPN Pharma Pvt Ltd | 58 |
| Hetero Drugs Limited | 58 |