Haloperidol | 52-86-8

Haloperidol Properties

Melting point	152 °C
Boiling point	529.0±50.0 °C(Predicted)
Density	1.1820 (estimate)
Flash point	9℃
storage temp.	2-8°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
form	powder
pka	8.3(at 25℃)
color	white
Water Solubility	2.058mg/L(22.5 ºC)
Merck	14,4598
BCS Class	4/3
CAS DataBase Reference	52-86-8(CAS DataBase Reference)
NIST Chemistry Reference	Haloperidol(52-86-8)
EPA Substance Registry System	Haloperidol (52-86-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H315-H317-H319-H335-H361

Precautionary statements

P201-P202-P280-P301+P310-P302+P352-P305+P351+P338

Hazard Codes

T,F

Risk Statements

60-61-25-36/37/38-43-39/23/24/25-23/24/25-11

Safety Statements

53-26-36/37/39-45-36/37-16

RIDADR

UN 2811 6.1/PG 3

WGK Germany

3

RTECS

EU1575000

HazardClass

6.1(b)

PackingGroup

III

HS Code

2933399090

Toxicity

LD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington)

NFPA 704

	0
2		0

Haloperidol price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H1512	Haloperidol powder	52-86-8	5G	₹12329.68	2022-06-14	Buy
Sigma-Aldrich(India)	PHR1724	Haloperidol Pharmaceutical Secondary Standard; Certified Reference Material	52-86-8	400MG	₹13574.55	2022-06-14	Buy
Sigma-Aldrich(India)	H1512	Haloperidol powder	52-86-8	10G	₹21974.75	2022-06-14	Buy
Sigma-Aldrich(India)	H1512	Haloperidol powder	52-86-8	25G	₹47586.7	2022-06-14	Buy
Sigma-Aldrich(India)	H-030	Haloperidol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?	52-86-8	1ML	₹3311.7	2022-06-14	Buy

Product number	Packaging	Price	Buy
H1512	5G	₹12329.68	Buy
PHR1724	400MG	₹13574.55	Buy
H1512	10G	₹21974.75	Buy
H1512	25G	₹47586.7	Buy
H-030	1ML	₹3311.7	Buy

Haloperidol Chemical Properties,Uses,Production

Description

Haloperidol is a butyrophenone with a long duration of action. It has lile α- adrenoceptor blocking activity and minimal effect on the cardiovascular system. It is an effective antiemetic but has a high incidence of extrapyramidal adverse effects. Haloperidol may be used in the short-term management of the acutely agitated patient (when sinister causes of confusion such as hypoxaemia and sepsis have been excluded) and in the management of delirium in ICU. The duration of action of haloperidol is approximately 24–48h.

Chemical Properties

White Crystalline Powder

Uses

Haloperidol is one of the most actively used modern neuroleptics. Its high antipsychotic activity is combined with a moderate sedative effect. It effectively stops various types of psychomotor excitement. It is used for schizophrenic psychoses, manic, paranoid, and delirious conditions, depression, psychomotor excitement of various origins, and for delirium and hallucinations of different origin.

Definition

ChEBI: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

General Description

Haloperidol, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4-fluorobutyrophenone (Haldol), is anodorless white to yellow crystalline powder. Haloperidol iswell and rapidly absorbed and has a high bioavailability. It ismore than 90% bound to plasma proteins. Haloperidol is excretedslowly in the urine and feces. About 30% of a dose isexcreted in urine and about 20% of a dose in feces via biliaryelimination,and only 1% of a dose is excreted as unchangeddrug in the urine.Haloperidol is a minor substrate of CYP1A2 and a major substrate of CYP2D6 and CYP3A4.CYP2D6 inhibitors may increase the levels/effects ofhaloperidol.Haloperidol may increase the levels/effects ofCYP2D6 substrates and it may decrease the bioactivationof CYP2D6 prodrugs substrates. Haloperidol also is a moderateinhibitor of CYP2D6 and CYP3A4. CYP3A4 inducersmay decrease the levels/effects of haloperidol, whereasCYP3A4 inhibitors may increase the levels/effects ofhaloperidol. Centrally acting acetylcholinesterase inhibitorsmay increase the risk of antipsychotic-related EPS. The precisemechanism of antipsychotic action is unclear but isconsidered to be associated with the potent DA D₂receptor–blocking activity in the mesolimbic system and theresulting adaptive changes in the brain. Haloperidol is usedprimarily for the long-term treatment of psychosis and is especiallyuseful in patients who are noncompliant with theirdrug treatment.

Pharmaceutical Applications

Haloperidol is an analogue of the dopamine D2 receptor antagonist and is an older antipsychotic drug. The drug is used in the treatment of schizophrenia, a neuropsychiatric disorder. In general, antipsychotic drugs work by blocking the dopamine D₂ receptors.
Haloperidol is such an antipsychotic drug, which was developed in the 1950s and entered the clinic soon after that. Its use is limited by the high incidence of extrapyramidal symptoms (movement disorders caused by drugs affecting the extrapyramidal system, a neural network which is part of the motor system). Nevertheless, haloperidol may be used for the rapid control of hyperactive psychotic states and is popular for treating restlessness in the elderly.

Biological Activity

Dopamine antagonist with selectivity for D 2 -like receptors (K i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). Subtype-selective NMDA antagonist.

Haloperidol Preparation Products And Raw materials

Raw materials

Butyrophenone Fluorobenzene Thionyl chloride Gamma Butyrolactone Ammonia

4-(4-chlorophenyl)piperidin-4-ol hydrochloride Hydrochloric acid

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Preparation Products

Haloperidol Suppliers

Global( 396)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
KARPSCHEM LABORATORIES	+91-7249203006 +91-7249203006	Maharashtra, India	786	58	Inquiry
Vamsi Labs Ltd	+91-2172357274 +91-9891966300	Maharashtra, India	43	58	Inquiry
R L Fine Chem Pvt. Ltd	+91-8042488999 +91-8042488999	Karnataka, India	74	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Lanz Labs Pvt Ltd	+91-2226205525 +91-2226205525	Maharashtra, India	5	58	Inquiry
Humble Healthcare Limited	+91-9720093000 +91-8006400378	Uttar Pradesh, India	141	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Globela Industry Pvt Ltd	+91-2616158000 +91-9998199919	Gujarat, India	98	58	Inquiry
Mankind Pharma Limited	+91-1146541111 +91-1146541111	New Delhi, India	23	58	Inquiry
RPG Life Sciences Ltd	+91-2266606375 +91-2266606375	Maharashtra, India	15	58	Inquiry

Supplier	Advantage
KARPSCHEM LABORATORIES	58
Vamsi Labs Ltd	58
R L Fine Chem Pvt. Ltd	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Lanz Labs Pvt Ltd	58
Humble Healthcare Limited	58
Ralington Pharma	58
Globela Industry Pvt Ltd	58
Mankind Pharma Limited	58
RPG Life Sciences Ltd	58

Haloperidol Spectrum

Haloperidol(52-86-8)MS Haloperidol(52-86-8)¹HNMR Haloperidol(52-86-8)¹³CNMR Haloperidol(52-86-8)IR1 Haloperidol(52-86-8)IR2 Haloperidol(52-86-8)Raman

52-86-8(Haloperidol)Related Search:

Triphenylmethyl Chloride tert-Butylchlorodiphenylsilane CHLOROPHOSPHONAZO III Chlorodimethylphenylsilane CHLOROPHENYLSILANE 97

IOHEXOL IMPURITY J IOHEXOL IMPURITY A Diphenoxylate 2-Butanone trifluperidol

HALOPERIDOL DECANOATE HALOPERIDOL METABOLITE III,Haloperidol metabolite III, R 11302 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide IOHEXOL RELATED COMPOUND C (100 MG) (N,N'- BIS(2,3-DIHYDROXYPROPYL)-5-NITRO-1,3-BENZENEDI- CARBOXAMIDE) HALOPERIDOL METABOLITE I,4-(4-Chlorophenyl)-4-hydroxypiperidine, 4-(4-Chlorophenyl)-4-piperidinol, Haloperidol metabolite I

Butylbenzene Iohexol HALOPERIDOL HYDROCHLORIDE

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4-(4-hydroxy-4’-chloro-4-phenylpiperidino)-4’-fluorobutyrophenone 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-4’-(4-flurophenyl)-1-butanone 4’-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-butyrophenon 4’-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone 4’-fluoro-4-(4-hydroxy-4-(4’-chlorophenyl)piperidino)butyrophenone 4’-fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone Aloperidin Aloperidol Aloperidolo Aloperidon Bioperidolo Brotopon Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- Dozic Einalon S einalons Eukystol fortunan Galoperidol gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone gamma-(4-(p-chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone gamma-(4-(p-chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone Halidol Halojust Halol Halopal Halopidol Halopoidol Halosten Keselan Lealgin compositum lealgincompositum Linton McM-JR-1625 McN-JR-1625 Mixidol Pekuces Peluces Pernox R 1625 HALOPERIDOL,USP Einalon 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanon 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4’-fluoro-butyrophenon 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone 4-(4-hydroxy-4’-chloro-4-phenylpiperidino)-4’-fluorbutyrophenone 4-(p-Chlorophenyl)-1-[4-(p-fluorophenyl)-4-hydroxybutyl]piperidin-4-ol 4-[4-(4-Chlorophenyl)-4-hydroxypiperidine-1-yl]-1-(4-fluorophenyl)butane-1-ol Haloperidol【reduced】 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobut 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4μ-fluorobutyrophenone, 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4μ-fluorobutyrophenone Haloperidol Base & Decanoate