フェニルプロピオン酸ナンドロロン 化学特性,用途語,生産方法
効能
タンパク同化薬, アンドロゲン受容体作動薬
化学的特性
White to Off-White Solid
使用
Anabolic steroid; androgen.
世界保健機関(WHO)
Nandrolone phenylpropionate, an anabolic steroid, was
introduced in 1959. In 1982, low dosage preparations were prohibited in
Bangladesh due to inadmissible promotion of products containing anabolic
steroids for malnourished children. Higher dosage preparations of nandrolone
phenylpropionate remain available in many countries, including Bangladesh, for
several highly specific but limited indications that apply to patients with chronic
debilitating and emaciating diseases, particularly associated with neoplasia and
some types of aplastic anaemia.
合成
Nandrolone phenylpropionate is prepared by reacting anhydrous MeCN with a mixture of 3-phenylpropanoic acid, aryneprecursor, nandrolone CsF, K2CO3, and 18-crown-6 in 70 ?? in an oil bath.
Add anhydrous MeCN (0.5 mL) to a mixture of 3-phenylpropanoic acid (30.0 mg, 0.2 mmol, 1.0 equiv), aryneprecursor (119.2 mg, 0.4 mmol, 2.0 equiv), nandrolone (82.3 mg, 0.3 mmol, 1.5 equiv), CsF (182.3 mg, 1.2 mmol, 6.0 equiv), K2CO3 (82.9 mg, 0.6 mmol, 3.0 equiv), and 18-crown-6 (158.6 mg, 0.6 mmol, 3.0 equiv). Warm the mixture to 70 ?? in an oil bath and stir at this temperature for8 hours. Remove all the volatiles directly on rotary evaporator. Purify by flash column chromatography with pet ether:EtOAc = 20:1. 1H NMR (400 MHz, CDCl3) |? 7.31-7.26(m,2H), 7.23-7.17(m,3H), 5.83 (s, lH), 4.65-4.58(m, lH), 2.95(t, J= 8.0 Hz,2H), 2.64(t, J= 8.0 Hz,2H), 2.51-2.36(m, 2H), 2.31-2.04(m, 5H), 1.86-1.79(m, 2H), 1.72-1.61 (m, 2H), 1.57-1.00(m, 8H),0.90-0.81(m, 1H), 0.79 (s, 3H)ppm.
Fig The synthetic method 1 of Nandrolone phenylpropionate
フェニルプロピオン酸ナンドロロン 上流と下流の製品情報
原材料
準備製品