Norgestrel
- CAS No.
- 6533-00-2
- Chemical Name:
- Norgestrel
- Synonyms
- sh850;wy3707;sh70850;monovar;Neogest;Ovrette;fh122-a;NORPLANT;OVRETTE(R);NORGESTREL
- CBNumber:
- CB2752440
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MOL File:
- 6533-00-2.mol
- Modify Date:
- 2024/7/2 8:55:04
| Melting point | 239-241 °C(lit.) |
|---|---|
| Boiling point | 392.36°C (rough estimate) |
| Density | 1.0697 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), Dichloromethane (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.09±0.40(Predicted) |
| color | Crystals from diethyl ether-hexane |
| InChIKey | WWYNJERNGUHSAO-XUDSTZEESA-N |
| CAS DataBase Reference | 6533-00-2(CAS DataBase Reference) |
| EPA Substance Registry System | Norgestrel (6533-00-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H360FD | |||||||||
| Precautionary statements | P202-P264-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JF8259000 | |||||||||
| HS Code | 2937230000 | |||||||||
| Toxicity | LD50 oral in rat: 5010mg/kg | |||||||||
| NFPA 704 |
|
Norgestrel Chemical Properties,Uses,Production
Description
Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component. In vivo, norgestrel administered via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.
Chemical Properties
White Solid
Uses
A metabolite of Norgestrel.
General Description
Norgestrel, (17α)-(±)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, and levonorgestrel, (17α)-(-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one,have a C13 ethyl group instead of the C13 methyl but haveprogestational properties similar to those of norethindrone,with decreased androgenic effects. The ethyl group apparentlyprovides unfavorable steric interactions with the ARthat reduce the affinity compared with that with the PRs.Norgestrel is a racemic mixture, while levonorgestrel is thesingle active levorotatory enantiomer. Norgestrel is usedonly in oral contraceptives. Levonorgestrel is used in bothoral combination birth control products and polymeric implantsthat provide contraception for up to 5 years.
Safety Profile
Human reproductive effects byingestion and implant: menstrual cycle changes ordisorders and female fertility index changes. Anexperimental teratogen. Experimental reproductiveeffects. Questionable carcinogen with experimentalneoplastigenic data. An o
Norgestrel Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| Prime Imports & Exports (Represent Bayer AG) | 91-22-22088579 | Maharashtra, India | 43 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| LUPIN LTD | +91 124 4885000 / +91 124 3325000 | New Delhi, India | 191 | 58 | Inquiry |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | China | 985 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21677 | 55 | Inquiry |
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