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Tandutinib

CAS No.: 387867-13-2

Chemical Name:: Tandutinib

Synonyms: CS-309;MLN 518;CT 53518;NSC726292;Tandutinib;Unii-E1io3icj9a;CT53518; MLN518;Tandutinib(TINIBS);MLN518, Tandutinib;Tandutinib (MLN518)

CBNumber:: CB31011758

Molecular Formula:: C31H42N6O4

Molecular Weight:: 562.7

MOL File:: 387867-13-2.mol

Modify Date:: 2024/6/7 20:51:53

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Tandutinib Properties

Melting point	177-178°C
Boiling point	769.5±60.0 °C(Predicted)
Density	1.213±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	13.39±0.70(Predicted)
form	Solid
color	White to Off-White
CAS DataBase Reference	387867-13-2(CAS DataBase Reference)

Tandutinib price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML2672	Tandutinib hydrochloride ≥98% (HPLC)	387867-13-2	25MG	₹5860.8	2022-06-14	Buy
Sigma-Aldrich(India)	SML2672	Tandutinib hydrochloride ≥98% (HPLC)	387867-13-2	100MG	₹11821.5	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML2672	25MG	₹5860.8	Buy
SML2672	100MG	₹11821.5	Buy

Tandutinib Chemical Properties,Uses,Production

Description

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC₅₀ = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC₅₀ = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

Chemical Properties

White Solid

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelody

Definition

ChEBI: An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 s replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

Tandutinib Preparation Products And Raw materials

Raw materials

Preparation Products

Tandutinib Suppliers

Global( 170)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	China	990	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	China	6387	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17367	58	Inquiry

Supplier	Advantage
Manus Aktteva	34
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Sinoway Industrial co., ltd.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58

387867-13-2(Tandutinib)Related Search:

5-Hydroxytryptophan Quizartinib (AC220) Linifanib (ABT-869) Dasatinib Masitinib

PD 0332991 HCl Ibrutinib Bosutinib 6,7-DIMETHOXY-4-PIPERAZIN-1-YL-QUINAZOLINE Tandutinib

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Tandutinib 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)- 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide Unii-E1io3icj9a Tandutinib(CT 53518) Tandutinib (MLN518) CT53518; MLN518 Tandutinib(TINIBS) (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide CT 53518 MLN 518 Tandutinib for research N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide NSC726292 (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide Tandutinib(MLN518) 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-Methylethoxy)phenyl]- N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1- MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518; Tandutinib (CT53518, MLN518) CS-309 Tandutinib（MLN518, CT53518） Tandutinib USP/EP/BP Tandutinib (MLN518, CT53518, NSC-726292) 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(... MLN518, Tandutinib Tandutinib CT53518 MLN518 CT-53518 MLN-518 387867-13-2 C31H42N6O4 C27H31Br2ClN4O2 Inhibitors ZUBRIN API Intermediates & Fine Chemicals Pharmaceuticals Tyrosine Kinase Inhibitors