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Linifanib (ABT-869)

Linifanib (ABT-869) Structure
CAS No.
796967-16-3
Chemical Name:
Linifanib (ABT-869)
Synonyms
RG3635;CS-178;ABT-869;AL-39324;Linifanib;Linifanib-d4;ABT-869 5.2G;AL39324,RG3635;Caswell No. 146;ABT-869、AL-39324
CBNumber:
CB52464951
Molecular Formula:
C21H18FN5O
Molecular Weight:
375.4
MOL File:
796967-16-3.mol
Modify Date:
2023/6/30 15:45:59

Linifanib (ABT-869) Properties

Melting point 180-183°C (dec.)
Boiling point 542.2±50.0 °C(Predicted)
Density 1.424
storage temp. -20°C Freezer
solubility DMSO, Methanol
pka 13.30±0.70(Predicted)
form Brown powder.
color Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Danger
Hazard statements  H410-H372-H361-H400
Precautionary statements  P273-P391-P501-P273-P391-P501-P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501
HS Code  2933998090

Linifanib (ABT-869) Chemical Properties,Uses,Production

Chemical Properties

Beige Solid

Uses

Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

Definition

ChEBI: A member of the class of ureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other nitrogen is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a poten , selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.

Linifanib (ABT-869) Preparation Products And Raw materials

Raw materials

Preparation Products

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Linifanib (ABT-869) Spectrum

796967-16-3(Linifanib (ABT-869))Related Search:

1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea Linifanib N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)- ABT-869 5.2G AL-39324 RG3635 ABT-869/Linifanib ABT-869 Urea, N-[4-(3-aMino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-Methylphenyl)-nifanib LINIFANIB ABT-869 ABT-869; AL-39324; RG3635 ABT-869(Linifanib)/AL-39324,RG3635 ABT-869、AL-39324 AL39324,RG3635 Linifanib N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea ABT 869 Linifanib (ABT-869) CS-178 1-(4-(3-amino-1H-indol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea ABT-869;AL-39324;ABT 869;ABT869;AL 39324;AL39324;RG3635 Linifanib (ABT-869) USP/EP/BP Linifanib-d4 Caswell No. 146 ABT-869|||RG3635|||AL-39324 796967-16-3 APIs Aromatics Heterocycles Tyrosine Kinase Inhibitors Growt Factors and Citokines. Inhibitors