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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Dihydropyridine >ARRY-424704, ARRY-704

ARRY-424704, ARRY-704

ARRY-424704, ARRY-704 Structure
  • ₹0
  • Product name: ARRY-424704, ARRY-704
  • CAS: 869357-68-6
  • MF: C16H17FIN3O4
  • MW: 461.23
  • EINECS:642-441-7
  • MDL Number:MFCD18384989
  • Synonyms:ARRY-424704, ARRY-704;AZD8330;2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide;ARRY424704;ARRY-424704;ARRY704;ARRY-704;AZD8330/ARRY-424704/arry-704/AZD8330/AZD-8330
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.732
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH
form :solid
pka :14.31±0.10(Predicted)
color :Off-white to pink

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.

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Suppliers and manufacturers

career henan chemical co
ARRY-424704, ARRY-704
₹1.00 /1KG
ARRY-424704, ARRY-704 CAS:869357-68-6
Shaanxi Dideu Medichem Co. Ltd
ARRY-424704, ARRY-704
₹1.10 /1g
ARRY-424704, ARRY-704 CAS:869357-68-6
Dideu Industries Group Limited
ARRY-424704, ARRY-704
₹1.10 /1g
ARRY-424704, ARRY-704 CAS:869357-68-6
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ANHUI WITOP BIOTECH CO., LTD
Zhejiang J&C Biological Technology Co.,Limited
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