2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
![2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid Structure](/CAS2/GIF/1173900-33-8.gif)
|
- ₹0
- Product name: 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
- CAS: 1173900-33-8
- MF: C22H24N4O4
- MW: 408.45
- EINECS:-0
- MDL Number:MFCD16659062
- Synonyms:2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid;AZD 6482;AZD6482(PI3-kinase β inhibitor);AZD-6482/AZD6482;AZD6482(r);(R)AZD64822-[[(1R)-1-[7-Methyl-2-(4-Morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyriMidin-9-yl]ethyl]aMino]benzoic acid;KIN-193;2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid AZD 6482
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Boiling point :635.5±65.0 °C(Predicted)
Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH
form :solid
pka :3.90±0.50(Predicted)
color :White to light yellow
Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH
form :solid
pka :3.90±0.50(Predicted)
color :White to light yellow
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively). It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases. AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss. AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice. It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.More related product prices
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- 1217486-61-7 GSK2636771 ABT-199 MK-2206 2HCl BKM120 (NVP-BKM120, Buparlisib) BMS-794833 371942-69-7 356559-20-1 675576-98-4 R428 Tozasertib NVP-BVU 972 ARRY-424704, ARRY-704 Binimetinib ChlorotrimethylsilaneRelated product price
- 356559-20-1
₹5300-83742.2 - 675576-98-4
₹30169.8-122444.1 - Tozasertib
₹7836.6
Suppliers and manufacturers
career henan chemical co
![2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid](https://img.chemicalbook.com/ProductImageEN/2018-8/small/5c80356e-28ed-46e0-8e40-ef35d7b6a689.png)
CLEARSYNTH LABS LTD.
Capot Chemical Co.,Ltd.
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
₹1.00 /1KG
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid CAS:1173900-33-8
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid CAS:1173900-33-8