TAK-733
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- ₹0
- Product name: TAK-733
- CAS: 1035555-63-5
- MF: C17H15F2IN4O4
- MW: 504.23
- EINECS:
- MDL Number:MFCD24386349
- Synonyms:TAK-733;TAK-733/TAK733;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione TAK 733;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrim;CS-547;3-[(2r)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione;Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-
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Properties
Boiling point :530.5±60.0 °C(Predicted)
Density :1.91±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥25.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :13.72±0.20(Predicted)
color :White to light yellow
Density :1.91±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥25.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :13.72±0.20(Predicted)
color :White to light yellow
Safety Information
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Description
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.Related product price
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