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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >Raf inhibitors >TAK-632

TAK-632

TAK-632 Structure
  • ₹0
  • Product name: TAK-632
  • CAS: 1228591-30-7
  • MF: C27H18F4N4O3S
  • MW: 554.52
  • EINECS:200-256-5
  • MDL Number:MFCD26960965
  • Synonyms:TAK-632;N-(7-CYANO-6-(4-FLUORO-3-(2-(3-(TRIFLUOROMETHYL)PHENYL)ACETAMIDO)PHENOXY)BENZO[D]THIAZOL-2-YL)CYCLOPROPANECARBOXAMIDE;N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide;TAK-0632;N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide TAK632;TAK 632 N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide;TAK-632, >=98%;TAK2 63 (Free base)
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥27.75 mg/mL in DMSO; insoluble in H2O; ≥2.23 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :9.59±0.70(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

TAK-632 is a slow off-rate inhibitor of Raf kinases (IC50s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively). It demonstrates 14-1,200-fold selectivity for Raf over a panel of 26 different kinases. TAK-632 shows significant antiproliferative activity against mutated B-Raf or mutated N-Ras cancer cell lines and xenograft models, inhibiting MEK phosphorylation with an IC50 value of 12 nM and downstream ERK phosphorylation with an IC50 value of 16 nM.

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Suppliers and manufacturers

career henan chemical co
TAK-632
₹5.00 /5KG
TAK-632 CAS:1228591-30-7
CLEARSYNTH LABS LTD. A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific