PP2
|
- ₹14450 - ₹29730
- Product name: PP2
- CAS: 172889-27-9
- MF: C15H16ClN5
- MW: 301.77
- EINECS:
- MDL Number:MFCD01568210
- Synonyms:[1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]amine;1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine;PP2(AG 1879);AGL 1879;PP 2 (enzyme inhibitor);Src kinase inhibitor PP2;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-;AG 1879,AGL 1879
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number529573
- Product descriptionPP2 - CAS 172889-27-9 - Calbiochem PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC?? = 4, 5, 5, &100 nM for p
- Packaging1MG
- Price₹14450
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP0042
- Product descriptionPP2 ≥98% (HPLC)
- Packaging5MG
- Price₹20762.35
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number529573
- Product descriptionPP2 - CAS 172889-27-9 - Calbiochem PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC?? = 4, 5, 5, &100 nM for p
- Packaging5MG
- Price₹29730
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 529573 | PP2 - CAS 172889-27-9 - Calbiochem PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC?? = 4, 5, 5, &100 nM for p | 1MG | ₹14450 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0042 | PP2 ≥98% (HPLC) | 5MG | ₹20762.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 529573 | PP2 - CAS 172889-27-9 - Calbiochem PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC?? = 4, 5, 5, &100 nM for p | 5MG | ₹29730 | 2022-06-14 | Buy |
Properties
Boiling point :493.5±40.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming).
pka :3.96±0.30(Predicted)
form :Off-white solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming).
pka :3.96±0.30(Predicted)
form :Off-white solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 μM), or ZAP-70 (IC50 > 100 μM). PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr577. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylation of human T-cells with an IC50 value of 600 nM.More related product prices
196868-63-0 PPQ-102 Pirimiphos-methyl Pirimiphos ethyl PP3 Paraquat dichloride TriphenylphosphineRelated product price
- 196868-63-0
₹17860-19116.95 - PPQ-102
₹21460 - PP1
₹21390.2-86112.88