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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea

IGF-1R  Inhibitor  II,  N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Structure
  • ₹17860 - ₹19116.95
  • Product name: IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
  • CAS: 196868-63-0
  • MF: C18H16ClN3O2
  • MW: 341.79
  • EINECS:
  • MDL Number:MFCD00160558
  • Synonyms:IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea;PQ401;N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea;IGF-1R Inhibitor II;N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea;Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-;1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea;N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number407248
  • Product descriptionIGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily
  • Packaging10MG
  • Price₹17860
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0113
  • Product descriptionPQ401 ≥98% (HPLC), powder
  • Packaging10MG
  • Price₹19116.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 407248 IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily 10MG ₹17860 2022-06-14 Buy
Sigma-Aldrich(India) P0113 PQ401 ≥98% (HPLC), powder 10MG ₹19116.95 2022-06-14 Buy

Properties

Density :1.370±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10mg/mL
form :White solid
color :white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PQ401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. The mechanism of inhibition likely involves indirect blocking of ATP binding. PQ401 also decreases IGF-1R-dependent tumor cell growth in vitro.

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