RESATORVID
|
- ₹11740 - ₹27080
- Product name: RESATORVID
- CAS: 243984-11-4
- MF: C15H17ClFNO4S
- MW: 361.82
- EINECS:
- MDL Number:MFCD11046362
- Synonyms:TAK-242(Resatorvid);1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester, (6R)-;Resatorvid(TAK-242);Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester, (6R)-;(R)-ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;RESATORVID;TAK 242;(6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 2MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number5.08336
- Product descriptionInSolution TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem A 25 mM (2 mg/221 μL) sterile-filtered solution of TLR4 Inhibitor, TAK-242 in DMSO.
- Packaging2MG
- Price₹11740
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number614316
- Product descriptionTLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor
- Packaging5MG
- Price₹27080
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 5.08336 | InSolution TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem A 25 mM (2 mg/221 μL) sterile-filtered solution of TLR4 Inhibitor, TAK-242 in DMSO. | 2MG | ₹11740 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 614316 | TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor | 5MG | ₹27080 | 2022-06-14 | Buy |
Properties
Melting point :68-69℃
Boiling point :462.0±55.0 °C(Predicted)
Density :1.39
storage temp. :Sealed in dry,Room Temperature
solubility :insoluble in H2O; ≥100.6 mg/mL in EtOH; ≥18.09 mg/mL in DMSO
form :Solid
pka :7.08±0.40(Predicted)
color :Off-white to yellow
Boiling point :462.0±55.0 °C(Predicted)
Density :1.39
storage temp. :Sealed in dry,Room Temperature
solubility :insoluble in H2O; ≥100.6 mg/mL in EtOH; ≥18.09 mg/mL in DMSO
form :Solid
pka :7.08±0.40(Predicted)
color :Off-white to yellow
Safety Information
| Symbol(GHS): |
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response. Alternatively, hypoxia or ischemia/reperfusion can trigger signaling through TLR4. TAK-242 is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. It does not affect signaling through other TLRs. TAK-242 is effective in vivo, suppressing the production of NO, TNF-α, IL-6, and IL-1β in mice treated with LPS when given intravenously. Mechanistically, TAK-242 acts by selectively binding TLR4 and preventing its association with adaptor proteins that are essential for signal transduction. TAK-242 is used to study signaling through TLR4 in a variety of pathologies, including sepsis and ischemia/reperfusion injury.More related product prices
Abiraterone Celastrol Rapamycin 381716-33-2 154229-18-2 Ethyl 2-oxocyclohexanecarboxylate 1268454-23-4 TAK-438 TAK-733 TAK-960 TAK-063Related product price
- Abiraterone
₹3200-9700 - Celastrol
₹20556.68-81772.05 - Rapamycin
₹4194-370089
