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ChemicalBook > Product Catalogue >Biochemical Engineering >Nucleoside drugs >Deoxynucleotides and their analogs >5-Aza-2'-deoxycytidine

5-Aza-2'-deoxycytidine

5-Aza-2'-deoxycytidine Structure
  • ₹5100 - ₹75387
  • Product name: 5-Aza-2'-deoxycytidine
  • CAS: 2353-33-5
  • MF: C8H12N4O4
  • MW: 228.21
  • EINECS:219-089-4
  • MDL Number:MFCD00043011
  • Synonyms:4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one;5-Aza-2'-deoxycytidine,98+%;4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;Decitabine(NSC127716);4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on ;4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one ;5-azadeoxycytidine ;5-triazin-2(1h)-one,4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-3
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Brand

  • ALFA India
  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 20MG
  • 25MG
  • 50MG
  • 100mg
  • 250mg
  • ManufacturerALFA India
  • Product numberALF-J65513-MC
  • Product description5-Aza-2'-deoxycytidine, 98%
  • Packaging100mg
  • Price₹16798
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-J65513-MD
  • Product description5-Aza-2'-deoxycytidine, 98%
  • Packaging250mg
  • Price₹75387
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2232
  • Product description5-Aza-2'-deoxycytidine
  • Packaging20MG
  • Price₹5100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2232
  • Product description5-Aza-2'-deoxycytidine
  • Packaging100MG
  • Price₹14500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3656
  • Product description5-Aza-2′-deoxycytidine ≥97%
  • Packaging5MG
  • Price₹12113.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number189826
  • Product descriptionInSolution 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumo
  • Packaging10MG
  • Price₹13100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3656
  • Product description5-Aza-2′-deoxycytidine ≥97%
  • Packaging10MG
  • Price₹19474.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number189825
  • Product description5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem A cytosine analog that acts as a DNA methyltransferase inhibitor.
  • Packaging25MG
  • Price₹34040
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3656
  • Product description5-Aza-2′-deoxycytidine ≥97%
  • Packaging50MG
  • Price₹71737.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-J65513-MC 5-Aza-2'-deoxycytidine, 98% 100mg ₹16798 2022-05-26 Buy
ALFA India ALF-J65513-MD 5-Aza-2'-deoxycytidine, 98% 250mg ₹75387 2022-05-26 Buy
TCI Chemicals (India) A2232 5-Aza-2'-deoxycytidine 20MG ₹5100 2022-05-26 Buy
TCI Chemicals (India) A2232 5-Aza-2'-deoxycytidine 100MG ₹14500 2022-05-26 Buy
Sigma-Aldrich(India) A3656 5-Aza-2′-deoxycytidine ≥97% 5MG ₹12113.18 2022-06-14 Buy
Sigma-Aldrich(India) 189826 InSolution 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumo 10MG ₹13100 2022-06-14 Buy
Sigma-Aldrich(India) A3656 5-Aza-2′-deoxycytidine ≥97% 10MG ₹19474.18 2022-06-14 Buy
Sigma-Aldrich(India) 189825 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem A cytosine analog that acts as a DNA methyltransferase inhibitor. 25MG ₹34040 2022-06-14 Buy
Sigma-Aldrich(India) A3656 5-Aza-2′-deoxycytidine ≥97% 50MG ₹71737.28 2022-06-14 Buy

Properties

Melting point :~200 °C (dec.)
alpha :D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water)
Boiling point :370.01°C (rough estimate)
Density :1.3771 (rough estimate)
refractive index :1.6590 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :acetic acid/water (1:1): 50 mg/mL
form :Powder
pka :14.02±0.60(Predicted)
color :White to Off-white
Merck :14,2853
BRN :617982
Stability :Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.
InChIKey :XAUDJQYHKZQPEU-KVQBGUIXSA-N
CAS DataBase Reference :2353-33-5(CAS DataBase Reference)
EPA Substance Registry System :5-Aza-2'-deoxycytidine (2353-33-5)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

5-Azacytidine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a 2’-deoxy analog of 5-azacytidine which similarly causes hypomethylation of DNA by inhibiting DNA methyltransferases in a concentration-dependent manner. This action is useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.

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