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ChemicalBook > Product Catalogue >Biochemical Engineering >Nucleoside drugs >Nucleotides and their analogs >5-Azacytidine

5-Azacytidine

5-Azacytidine Structure
  • ₹570 - ₹86409
  • Product name: 5-Azacytidine
  • CAS: 320-67-2
  • MF: C8H12N4O5
  • MW: 244.2
  • EINECS:206-280-2
  • MDL Number:MFCD00006539
  • Synonyms:Antibiotic U 18496-15N4;Azacitidine-15N4;Azacytidine-15N4;LadakaMycin-15N4;LedakaMycin-15N4;Mylosar-15N4;NSC 102816-15N4;NSC 103-627-15N4
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • SRL
  • ottokemi

Package

  • 25mg
  • 100MG
  • 250MG
  • 300MG
  • 1gm
  • 1G
  • 5gm
  • 25gm
  • 1VIAL
  • 1Gms
  • ManufacturerTCI Chemicals (India)
  • Product numberA2033
  • Product description5-Azacytidine
  • Packaging100MG
  • Price₹2100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2033
  • Product description5-Azacytidine
  • Packaging1G
  • Price₹5600
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1287
  • Product description5-Azacytidine Hybri-Max?, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
  • Packaging1VIAL
  • Price₹2478.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2385
  • Product description5-Azacytidine ≥98% (HPLC)
  • Packaging100MG
  • Price₹5715.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2385
  • Product description5-Azacytidine ≥98% (HPLC)
  • Packaging250MG
  • Price₹11875.03
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1911
  • Product descriptionAzacitidine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging300MG
  • Price₹39576.2
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberA2385
  • Product description5-Azacytidine ≥98% (HPLC)
  • Packaging1G
  • Price₹40994.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSRL
  • Product number34476
  • Product description5-Azacytidine extrapure, 98%
  • Packaging25mg
  • Price₹570
  • Updated2022-05-26
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  • ManufacturerSRL
  • Product number34476
  • Product description5-Azacytidine extrapure, 98%
  • Packaging100mg
  • Price₹1750
  • Updated2022-05-26
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  • ManufacturerSRL
  • Product number34476
  • Product description5-Azacytidine extrapure, 98%
  • Packaging1Gms
  • Price₹4730
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 6775
  • Product description5-Azacytidine, ≥98% (HPLC)
  • Packaging100mg
  • Price₹2196
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 6775
  • Product description5-Azacytidine, ≥98% (HPLC)
  • Packaging250mg
  • Price₹3969
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 6775
  • Product description5-Azacytidine, ≥98% (HPLC)
  • Packaging1gm
  • Price₹5094
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 6775
  • Product description5-Azacytidine, ≥98% (HPLC)
  • Packaging5gm
  • Price₹24039
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 6775
  • Product description5-Azacytidine, ≥98% (HPLC)
  • Packaging25gm
  • Price₹86409
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A2033 5-Azacytidine 100MG ₹2100 2022-05-26 Buy
TCI Chemicals (India) A2033 5-Azacytidine 1G ₹5600 2022-05-26 Buy
Sigma-Aldrich(India) A1287 5-Azacytidine Hybri-Max?, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma 1VIAL ₹2478.93 2022-06-14 Buy
Sigma-Aldrich(India) A2385 5-Azacytidine ≥98% (HPLC) 100MG ₹5715.6 2022-06-14 Buy
Sigma-Aldrich(India) A2385 5-Azacytidine ≥98% (HPLC) 250MG ₹11875.03 2022-06-14 Buy
Sigma-Aldrich(India) PHR1911 Azacitidine Pharmaceutical Secondary Standard; Certified Reference Material 300MG ₹39576.2 2022-06-14 Buy
Sigma-Aldrich(India) A2385 5-Azacytidine ≥98% (HPLC) 1G ₹40994.28 2022-06-14 Buy
SRL 34476 5-Azacytidine extrapure, 98% 25mg ₹570 2022-05-26 Buy
SRL 34476 5-Azacytidine extrapure, 98% 100mg ₹1750 2022-05-26 Buy
SRL 34476 5-Azacytidine extrapure, 98% 1Gms ₹4730 2022-05-26 Buy
ottokemi A 6775 5-Azacytidine, ≥98% (HPLC) 100mg ₹2196 2022-05-26 Buy
ottokemi A 6775 5-Azacytidine, ≥98% (HPLC) 250mg ₹3969 2022-05-26 Buy
ottokemi A 6775 5-Azacytidine, ≥98% (HPLC) 1gm ₹5094 2022-05-26 Buy
ottokemi A 6775 5-Azacytidine, ≥98% (HPLC) 5gm ₹24039 2022-05-26 Buy
ottokemi A 6775 5-Azacytidine, ≥98% (HPLC) 25gm ₹86409 2022-05-26 Buy

Properties

Melting point :226-232 °C (dec.)(lit.)
alpha :40 º (C=1, H2O 22 ºC)
Boiling point :387.12°C (rough estimate)
Density :1.4287 (rough estimate)
refractive index :1.6590 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
pka :13.46±0.70(Predicted)
form :lyophilized powder
color :White to Off-white
Water Solubility :0.5-1.0 g/100 mL at 21 ºC
Merck :14,887
BRN :620461
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey :NMUSYJAQQFHJEW-WGDKFINWSA-N
LogP :-2.191 (est)
CAS DataBase Reference :320-67-2(CAS DataBase Reference)
IARC :2A (Vol. 50) 1990
EPA Substance Registry System :Azacitidine (320-67-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines). 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.

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