5-Aza-2'-deoxycytidine
- CAS No.
- 2353-33-5
- Chemical Name:
- 5-Aza-2'-deoxycytidine
- Synonyms
- DECITABINE;Dacogen;5-AZA-CDR;5-AZA-DC;CS-1979;Decitabin;NSC 127716;Aza deoxycytidine;5-azadeoxycytidine;Ornidazole 2353-33-5
- CBNumber:
- CB6284800
- Molecular Formula:
- C8H12N4O4
- Molecular Weight:
- 228.21
- MOL File:
- 2353-33-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/18 18:48:51
| Melting point | ~200 °C (dec.) |
|---|---|
| alpha | D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water) |
| Boiling point | 370.01°C (rough estimate) |
| Density | 1.3771 (rough estimate) |
| refractive index | 1.6590 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | acetic acid/water (1:1): 50 mg/mL |
| form | Powder |
| pka | 14.02±0.60(Predicted) |
| color | White to Off-white |
| Merck | 14,2853 |
| BRN | 617982 |
| Stability | Stable. May be light or air sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| CAS DataBase Reference | 2353-33-5(CAS DataBase Reference) |
| EPA Substance Registry System | 5-Aza-2'-deoxycytidine (2353-33-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H335-H341-H360 | |||||||||
| Precautionary statements | P201-P202-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn,Xi,T | |||||||||
| Risk Statements | 22-36/37/38-68-61 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XZ3012000 | |||||||||
| F | 10-34 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 190 i.p. (Momparler, 1985) | |||||||||
| NFPA 704 |
|
5-Aza-2'-deoxycytidine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A3656 | 5-Aza-2′-deoxycytidine ≥97% | 2353-33-5 | 5MG | ₹12113.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A3656 | 5-Aza-2′-deoxycytidine ≥97% | 2353-33-5 | 10MG | ₹19474.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A3656 | 5-Aza-2′-deoxycytidine ≥97% | 2353-33-5 | 50MG | ₹71737.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 189826 | InSolution 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumo | 2353-33-5 | 10MG | ₹13100 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 189825 | 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem A cytosine analog that acts as a DNA methyltransferase inhibitor. | 2353-33-5 | 25MG | ₹34040 | 2022-06-14 | Buy |
5-Aza-2'-deoxycytidine Chemical Properties,Uses,Production
Description
Decitabine, 5-aza-2’-deoxycytidine, has been launched for the treatment of myelodysplastic syndromes (MDS). MDS are a set of hematologic disorders affecting the bone marrow that result in ineffective formation and development of blood cells. Furthermore, patients with MDS have a high risk of progressing to acute myeloid leukemia (AML). Traditional treatments include blood transfusions, hematopoietic growth factors, and prophylactic antibiotics, but these measures merely improve the quality of life with questionable effects on disease modification. While stem-cell transplantation is an aggressive, potentially curative approach, the advanced age or the other complicating health issues of most patients preclude them from considering this option. Recent advances in the underlying etiology of MDS, however, have led to the development of a new class of compounds known as ‘‘demethylating agents’’. Decitabine follows the successful introduction of the first DNA methyltransferase inhibitor azacitidine.
Chemical Properties
white crystalline powder
Uses
Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.
General Description
Fine white crystalline powder. Used as a drug.
Air & Water Reactions
Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour .
Reactivity Profile
5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible.
Biological Activity
Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
Safety Profile
Poison by intravenous route.Human mutation data reported. When heated todecomposition it emits toxic fumes of NOx.
5-Aza-2'-deoxycytidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Fresenius Kabi Oncology Limited | +91-1243325000 +91-1244885000 | Haryana, India | 22 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
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