ChemicalBook > Product Catalog >API >Antineoplastic agents >Antimetabolites, Antineoplastic >Floxuridine
Floxuridine
- CAS No.
- 50-91-9
- Chemical Name:
- Floxuridine
- Synonyms
- FUDR;5-FUDR;FDUR;5-FLUORODEOXYURIDINE;5-FLUORO-2-DEOXYURIDINE;5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;Floxuridin;Floxuridine (250 mg);FUD;FDURD
- CBNumber:
- CB3210097
- Molecular Formula:
- C9H11FN2O5
- Molecular Weight:
- 246.19
- MOL File:
- 50-91-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/11 17:37:18
| Melting point | 148 °C(lit.) |
|---|---|
| Boiling point | 150 °C |
| alpha | 35.9 º (c=1, water) |
| Density | 1.3751 (estimate) |
| storage temp. | room temp |
| solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| pka | pKa 7.44 (Uncertain) |
| form | Powder |
| color | White to almost white |
| Water Solubility | soluble |
| Merck | 14,4112 |
| BRN | 2645818 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | ODKNJVUHOIMIIZ-GFCOJPQKSA-N |
| CAS DataBase Reference | 50-91-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Uridine, 2'-deoxy-5-fluoro-(50-91-9) |
| EPA Substance Registry System | Floxuridine (50-91-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 22-68-36/37/38-40-20/21/22 | |||||||||
| Safety Statements | 22-36-36/37/39-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YU7525000 | |||||||||
| F | 10-23 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 oral in rat: 215mg/kg | |||||||||
| NFPA 704 |
|
Floxuridine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F0503 | 5-Fluoro-2′-deoxyuridine thymidylate synthase inhibitor | 50-91-9 | 100MG | ₹23295.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F0503 | 5-Fluoro-2′-deoxyuridine thymidylate synthase inhibitor | 50-91-9 | 250MG | ₹61756.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2589 | Floxuridine pharmaceutical secondary standard, certified reference material | 50-91-9 | 500MG | ₹16995.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F0503 | 5-Fluoro-2′-deoxyuridine thymidylate synthase inhibitor | 50-91-9 | 1G | ₹118241.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 343333 | 5-Fluoro-2ʹ-deoxyuridine - CAS 50-91-9 - Calbiochem Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinoma | 50-91-9 | 50MG | ₹8210 | 2022-06-14 | Buy |
Floxuridine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Floxuridine USP is used in Palliative treatment of gastrointestinal adenocarcinoma with liver metastases.
Definition
ChEBI: A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
General Description
Inhibits DNA synthesis.
Health Hazard
ACUTE/CHRONIC HAZARDS: Floxuridine is highly toxic by ingestion.
Fire Hazard
Flash point data for Floxuridine are not available, but Floxuridine is probably combustible.
Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: hypermotitity, diarrhea, nausea, vomiting and other gastrointestinal effects, allergic dermatitis, and bone marrow changes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Fand NOx.
Floxuridine Preparation Products And Raw materials
Global( 439)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Jysrox Pharmaceuticals Pvt Ltd | +91-8978794968 +91-8978794968 | Telangana, India | 11 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| Oceanic Pharmachem Pvt. Ltd. | 91-22-42128600 | Maharashtra, India | 2006 | 58 | Inquiry |
| Gagri Global IT Services Pvt. Ltd. | +91-40-27170174, | Telangana, India | 1321 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Jysrox Pharmaceuticals Pvt Ltd | 58 |
| Merit International | 58 |
| Oceanic Pharmachem Pvt. Ltd. | 58 |
| Gagri Global IT Services Pvt. Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |
50-91-9(Floxuridine)Related Search:
5-FDU
5-FLOXURIDINE
5-FLUORO-1-((2R,4S,5R)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDINE-2,4-DIONE
5-FLUORO-2'-DEOXY-BETA-URIDINE
(+)-5-FLUORO-2'-DEOXYURIDINE
5-FLUORO-2'-DEOXYURIDINE
2-DEOXY-5'-FLUOROURIDINE
1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-5-FLUOROURACIL
FDURD
fluorodeoxyuridine
fluoruridine deoxyribose
FLOXURIDINE
Fluoxuridine
2'-DFUR
Deoxyfluorouridine,98%
5-Fluoro-2'-deoxyuridine (FUDR)
(+)-5-FLUORODEOXYURIDINE, 98+%
5-FLURO-2’-DEOXYURIDINE
Floxuridine(5-Fudr)
5-Fluoro-2'-deoxyuridine,98+%
(+)-5-Fluoro-2'-deoxyuridine, 99+%
1-(2-Deoxy-b-D-ribofuranosyl)-5-fluorouracil
FUD
2'-Deoxy-5-fluoro-D-uridine
5-Fluoro-2'-deoxyuridine 98%
beta-5-fluoro-2’-deoxyuridine
beta-5-Fluoro-2'-deoxyuridine
Deoxyfluorouridine
Nsc 27640
NSC-26740
nsc27640
nsc-27640
Ro 5-0360
ro5-0360
Uridine, 2'-deoxy-5'-fluoro-
FLOSCHRYSANTHEMI.P.E
2''-DEOXY-5-FLUOROURIDINE (FLOXURIDINE)
FLOXURIDINE (2''-DEOXY-5-FLUOROURIDINE)
2'-DEOXY-5-FLUOROURIDINE
1-(2-Deoxy--D-ribofuranosyl)-5-fluorouracil
5-FLURO-2-DEOXYURIDINE extrapure
2μ-Deoxy-5-fluorouridine, Floxuridine, FUDR
5-F-2'--dU
Floxuridine API
1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
5-Fluoro-2'-deoxy-beta-uridine
Floxuridine
FUDR
2'-deoxy-5-fluorouridine 5'-phosphate
5-fluoro-1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione
Floxuridine (Fludara)
Fluoro-2′-deoxyuri
5-fluoro-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
5-fluoro-1-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone
5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]pyrimidine-2,4-dione
5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
5-Fluoro-2'-de
5-FDU, 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
5-Fluoro-2&priMe