Thymidine
- CAS No.
- 50-89-5
- Chemical Name:
- Thymidine
- Synonyms
- DT;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione;Deoxythymidine;β-Thymidine;b-Thymidine;Thymidin;Deoxyribothymidine;-Methylvalerophenone;THYMINE-2-DEOXYRIBOSIDE;Tyrosinase-related protein 2
- CBNumber:
- CB6134417
- Molecular Formula:
- C10H14N2O5
- Molecular Weight:
- 242.23
- MOL File:
- 50-89-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/28 13:53:24
| Melting point | 186-188 °C(lit.) |
|---|---|
| alpha | 18.6 º (c=3, H2O) |
| Boiling point | 385.05°C (rough estimate) |
| Density | 1.3129 (rough estimate) |
| refractive index | 33 ° (C=1, 1mol/L NaOH) |
| storage temp. | 2-8°C |
| solubility | Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P |
| pka | pK1:9.79;pK2:12.85 (25°C) |
| form | Crystalline Powder |
| color | White to almost white |
| PH | 9.8 |
| optical activity | [α]20/D +19±1°, c = 1% in H2O |
| Water Solubility | SOLUBLE |
| λmax | 267 (pH 7)；267 (pH 13) |
| Merck | 14,9397 |
| BRN | 89285 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | IQFYYKKMVGJFEH-XLPZGREQSA-N |
| LogP | -0.930 |
| CAS DataBase Reference | 50-89-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Thymidine(50-89-5) |
| EPA Substance Registry System | Thymidine (50-89-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-40-36/37/38-68 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XP2071000 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Thymidine price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T9250 | Thymidine ≥99% | 50-89-5 | 1G | ₹2024.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9250 | Thymidine ≥99% | 50-89-5 | 5G | ₹5899.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9250 | Thymidine ≥99% | 50-89-5 | 10G | ₹10446.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9250 | Thymidine ≥99% | 50-89-5 | 25G | ₹23490.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T1895 | Thymidine powder, BioReagent, suitable for cell culture | 50-89-5 | 1G | ₹4280 | 2022-06-14 | Buy |
Thymidine Chemical Properties,Uses,Production
Description
Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G1/early S phase.
Chemical Properties
White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.
Physical properties
Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.
Uses
Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.
Definition
ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.
General Description
Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.
Mechanism of action
High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase.
Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).
Thymidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Neugen Labs | +91-8133254502 +91-8133254502 | Karnataka, India | 195 | 58 | Inquiry |
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
| FINAR LTD | +91 - 2717 - 616717 | New Delhi, India | 660 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Neugen Labs | 58 |
| Orgamine Chemicals(I) Pvt Ltd | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Euroasia Trans Continental | 47 |
| FINAR LTD | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| ALPHA CHEMIKA | 43 |
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- Jul 25，2024
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