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SB 202190

CAS No.: 152121-30-7

Chemical Name:: SB 202190

Synonyms: FHPI;CS-403;CS-1907;CS-1908;SB202109;AI302281;SB 202190;AI3 02281;AI3-02281;Aids110355

CBNumber:: CB5478725

Molecular Formula:: C20H14FN3O

Molecular Weight:: 331.34

MOL File:: 152121-30-7.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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SB 202190 Properties

Melting point	240-243℃
Boiling point	565.7±50.0 °C(Predicted)
Density	1.31
RTECS	SL4584000
storage temp.	2-8°C
solubility	DMSO: 30 mg/mL, soluble
pka	9.14±0.15(Predicted)
form	Pale yellow solid
color	pale yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey	QHKYPYXTTXKZST-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

HS Code

29333990

NFPA 704

	0
2		0

SB 202190 price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	S7067	SB 202190 ≥98% (HPLC)	152121-30-7	5MG	₹12589.48	2022-06-14	Buy
Sigma-Aldrich(India)	S7067	SB 202190 ≥98% (HPLC)	152121-30-7	25MG	₹50292.95	2022-06-14	Buy
Sigma-Aldrich(India)	559397	InSolution SB 202190 - CAS 152121-30-7 - Calbiochem	152121-30-7	1ML	₹19050	2022-06-14	Buy

Product number	Packaging	Price	Buy
S7067	5MG	₹12589.48	Buy
S7067	25MG	₹50292.95	Buy
559397	1ML	₹19050	Buy

SB 202190 Chemical Properties,Uses,Production

Description

SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs). Pyridinyl imidazole inhibitors, including this compound, directly bind p38 MAP kinases in the ATP binding pocket. Recently, SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.

Definition

ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-act vated protein kinase (MAPK) alpha and beta.

General Description

A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (K_i = 16 nM; IC₅₀ = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC₅₀ = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.

Biological Activity

A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC 50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Also available as part of the MAPK Inhibitor Tocriset™ .

SB 202190 Preparation Products And Raw materials

Raw materials

2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE 4-Fluoro-N-methoxy-N-methylbenzamide 4-Fluorobenzoyl chloride

4-Methylpyridine 4-Hydroxybenzaldehyde

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Preparation Products

SB 202190 Suppliers

Global( 206)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16216	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29897	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58

SB 202190 Spectrum

SB 202190(152121-30-7)¹HNMR

152121-30-7(SB 202190)Related Search:

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Trametinib SB 203580 SCH772984 Ispinesib 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

SB242235 SB-705498 4'-CHLORO-3-METHOXYCINNAMANILIDE 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline SB1317

SB 269970 HYDROCHLORIDE 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 431542

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4-[4-(4-FLUOROPHENYL)-5-(4-PYRIDINYL)-1H-IMIDAZOL-2-YL]PHENOL 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-2H-imidazol-2-yl)phenol Aids110355 Aids-110355 Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]- SB 202190 SB 202190,4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-iMidazol-2-yl)phenol 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole SB 202190 SB202109 SB 202190, >=98% InSolution? SB 202190 SB202190 (FHPI) CS-403 2-(2-allylcarbamoylimino-5-nitro-thiazol-3-yl)-N-carbamoyl-acetamide InSolution SB 202190 - CAS 152121-30-7 - Calbiochem SB 202190 - CAS 152121-30-7 - Calbiochem CS-1907 CS-1908 SB-202190; SB 202190 2-(4-hydroxy-phenyl-)-4-(4-fluoro-phenyl-)-5-(pyrid-4-yl)-imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazole SB 202190 ISO 9001：2015 REACH AI3 02281 AI302281 AI3-02281 FHPI 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydro-2H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one 4-[4-(4-Fluorophenyl)-5-(4-pyridyl)-2-imidazolyl]phenol 152121-30-7 52121-30-7 C20H14FN3O C20H14N3OF Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors p38 Mitogen-Activated protein kinase (p38MAPK) BioChemical Cell Signaling and Neuroscience Cell Biology Inhibitors inhibitor