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SB-756050

SB-756050 Structure
CAS No.
447410-57-3
Chemical Name:
SB-756050
Synonyms
SB-756050;SB-756050, >98%;SB756050;SB 756050;SB-756050;1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane;1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-;G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19
CBNumber:
CB93162605
Molecular Formula:
C21H28N2O8S2
Molecular Weight:
500.59
MOL File:
447410-57-3.mol
Modify Date:
2024/7/2 8:55:41
Request For Quotation

SB-756050 Properties

Boiling point 653.1±65.0 °C(Predicted)
Density 1.328±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka -6.97±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
NFPA 704
0
2 0

SB-756050 Chemical Properties,Uses,Production

Description

SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 μM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.

SB-756050 Preparation Products And Raw materials

Raw materials

Preparation Products

SB-756050 Suppliers

Global( 49)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Luofa Biochemical Technology Co., Ltd. 021-51111890 15317326293 China 4196 58 Inquiry
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 China 8014 62 Inquiry
Jiangxi Jianglan Pure Biological Reagent Co., Ltd. 021-54720761 CHINA 6136 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Guangzhou Weijia Technology Co., Ltd. 020-84224925 18300190102 CHINA 6748 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Luofa Biochemical Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Jiangxi Jianglan Pure Biological Reagent Co., Ltd. 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Guangzhou Weijia Technology Co., Ltd. 58

SB-756050 Spectrum

SB-756050(447410-57-3)1HNMR

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SB-756050 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane SB756050;SB 756050;SB-756050 SB-756050, >98% 1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro- G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19 447410-57-3